BDBM224176 5-{6-(5- chloropyridin-3-yl)- 8-[(3r)-3-(2- fluorophenyl)morpho- lin-4-yl]-7-[(trans-4- methylcyclohexyl) methyl]-7h-purin-2-yl}- 1,3,4-oxadiazol- 2(3h)-one::US9540377, 16.95
SMILES C[C@H]1CC[C@H](Cn2c(nc3nc(nc(-c4cncc(Cl)c4)c23)-c2n[nH]c(=O)o2)N2CCOC[C@H]2c2ccccc2F)CC1
InChI Key
Data 1 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 1 hit for monomerid = 224176
Affinity DataIC50: 0.494nMT: 2°CAssay Description:An HDM2 FRET assay was developed to assess the compounds' inhibitory activity towards binding of p53 protein. A truncated version of HDM2 with re...More data for this Ligand-Target Pair