BDBM224323 3-{6-(5-chloropyridin-3-yl)-7-[1- (trans-4-methylcyclohexyl)ethyl]-8- [(2s)-2-(trifluoromethyl)pyrrolidin- 1-yl]-7h-purin-2-yl}-1,2,4- oxadiazol-5(4h)-one (mixture of diastereomers)::US9540377, 18.49
SMILES CC([C@H]1CC[C@H](C)CC1)n1c(nc2nc(nc(-c3cncc(Cl)c3)c12)-c1noc(=O)[nH]1)N1CCC[C@H]1C(F)(F)F
InChI Key
Data 1 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 1 hit for monomerid = 224323
Affinity DataIC50: 0.670nMT: 2°CAssay Description:An HDM2 FRET assay was developed to assess the compounds' inhibitory activity towards binding of p53 protein. A truncated version of HDM2 with re...More data for this Ligand-Target Pair