BDBM230772 US9340537, 26::US9896444, Example 26

SMILES CN(CCO)c1ncc(cc1-c1ccn[nH]1)C(=O)Nc1ccc(SC(F)(F)F)cc1

InChI Key InChIKey=OZUJXIBTTXJPEX-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 230772   

TargetTyrosine-protein kinase ABL1 [64-515](Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM230772(US9340537, 26 | US9896444, Example 26)
Affinity DataIC50:  1nMAssay Description:Caliper ABL1 (64-515) Assay: The assay plates were prepared by addition of 50 nL per well of compound solution in 90% DMSO. The kinase reactions were...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase ABL1 [64-515](Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM230772(US9340537, 26 | US9896444, Example 26)
Affinity DataIC50:  11nMAssay Description:Radio ABL1 (64-515) Assay: For determination of ABL kinase activity, the radiometric filter-binding assay was used. The assay was performed by mixing...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent