BDBM22416 (3S,4R)-3-[(1,3-benzodioxol-5-yloxy)methyl]-4-(4-fluorophenyl)piperidine::(3S,4R)-3-[(2H-1,3-benzodioxol-5-yloxy)methyl]-4-(4-fluorophenyl)piperidine::CHEMBL490::PAROXETINE::US09969700, Paroxetine::US9944618, Compound ID No. 182::[3H]Paroxetine
SMILES Fc1ccc(cc1)[C@@H]1CCNC[C@H]1COc1ccc2OCOc2c1
InChI Key InChIKey=AHOUBRCZNHFOSL-YOEHRIQHSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 11 hits for monomerid = 22416
Affinity DataKi: 0.800nMAssay Description:SERT: This protocol was designed to measure inhibition of uptake by the human serotonin transporter. The reagents were human SERT (HEK293F) cells, fl...More data for this Ligand-Target Pair
TargetMuscarinic acetylcholine receptor M3(Homo sapiens (Human))
Mayo Foundation
Curated by PDSP Ki Database
Mayo Foundation
Curated by PDSP Ki Database
Affinity DataKi: 145nMAssay Description:NET: This protocol was designed to measure inhibition of uptake by the human norepinephrine transporter. The reagents were human NET (HEK293F) cells,...More data for this Ligand-Target Pair
TargetMuscarinic acetylcholine receptor M1(Homo sapiens (Human))
Mayo Foundation
Curated by PDSP Ki Database
Mayo Foundation
Curated by PDSP Ki Database
TargetMuscarinic acetylcholine receptor M4(Homo sapiens (Human))
Mayo Foundation
Curated by PDSP Ki Database
Mayo Foundation
Curated by PDSP Ki Database
TargetMuscarinic acetylcholine receptor M2(Homo sapiens (Human))
Mayo Foundation
Curated by PDSP Ki Database
Mayo Foundation
Curated by PDSP Ki Database
Affinity DataKi: 388nMAssay Description:DAT: This protocol was designed to measure inhibition of uptake by the human dopamine transporter. The reagents were human DAT (HEK293F) cells, GBR 1...More data for this Ligand-Target Pair
TargetMuscarinic acetylcholine receptor M5(Homo sapiens (Human))
Mayo Foundation
Curated by PDSP Ki Database
Mayo Foundation
Curated by PDSP Ki Database
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Mayo Foundation
US Patent
Mayo Foundation
US Patent
Affinity DataIC50: 5.40E+3nMAssay Description:HERG: The pre- and post-compound hERG current was evoked by a single voltage pulse consisting of a 20 s period holding at −70 mV, a 160 ms step...More data for this Ligand-Target Pair
Affinity DataIC50: 2.00E+4nMAssay Description:Cytochrome P450 3A4 and 2D6:Recombinant enzymes, 3A4 and 2D6, generated using the ABL yeast expression system were used. For CYP3A4, the enzyme amou...More data for this Ligand-Target Pair
Affinity DataIC50: 3.10E+3nMAssay Description:Cytochrome P450 3A4 and 2D6:Recombinant enzymes, 3A4 and 2D6, generated using the ABL yeast expression system were used. For CYP3A4, the enzyme amou...More data for this Ligand-Target Pair