BDBM50227083 CHEMBL173443

SMILES CCCCCc1ccc(\C=C\C(=O)Nc2ccccc2C(O)=O)cc1

InChI Key InChIKey=GAMRBCZMOOMBSQ-CCEZHUSRSA-N

Data  9 IC50  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50227083   

TargetTransient receptor potential cation channel subfamily M member 2(Homo sapiens (Human))
Peking University

Curated by ChEMBL
LigandPNGBDBM50227083(CHEMBL173443)
Affinity DataIC50:  1.70E+3nMAssay Description:Inhibition of human TRPM2 expressed in HEK293 cells assessed as reduction in ADPR-induced channel currents by whole cell patch clamp electrophysiolog...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily M member 2(Homo sapiens (Human))
Peking University

Curated by ChEMBL
LigandPNGBDBM50227083(CHEMBL173443)
Affinity DataIC50:  320nMAssay Description:Inhibition of human TRPM2 expressed in HEK293 cells assessed as reduction in ADPR-induced channel currents treated extracellularly after 60 secs by w...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily M member 8(Homo sapiens (Human))
Peking University

Curated by ChEMBL
LigandPNGBDBM50227083(CHEMBL173443)
Affinity DataIC50:  3.90E+3nMAssay Description:Inhibition of human TRPM8 expressed in HEK293 cells assessed as reduction in H2O2-induced intracellular calcium flux after 30 mins by Fluo4-AM dye ba...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily M member 2(Homo sapiens (Human))
Peking University

Curated by ChEMBL
LigandPNGBDBM50227083(CHEMBL173443)
Affinity DataIC50:  1.70E+3nMAssay Description:Inhibition of human TRPM2 expressed in HEK293 cells assessed as reduction in H2O2-induced intracellular calcium flux after 30 mins by Fluo4-AM dye ba...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed