BDBM92862 US9284315, BEZ-235::mTOR Inhibitor, BEZ235
SMILES Cn1c2cnc3ccc(cc3c2n(-c2ccc(cc2)C(C)(C)C#N)c1=O)-c1cnc2ccccc2c1
InChI Key InChIKey=JOGKUKXHTYWRGZ-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 8 hits for monomerid = 92862
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform(Human)
Chongqing University
Curated by ChEMBL
Chongqing University
Curated by ChEMBL
Affinity DataEC50: 15nMAssay Description:Inhibition of PI3K-beta (unknown origin) after 40 mins by Kinase-Glo assayMore data for this Ligand-Target Pair
TargetPhosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Human)
Chongqing University
Curated by ChEMBL
Chongqing University
Curated by ChEMBL
Affinity DataEC50: 40nMAssay Description:Inhibition of recombinant full length PI3K p110alpha/p85alpha (unknown origin) expressed in baculovirus infected sf9 cells using PIP2 as substrate pr...More data for this Ligand-Target Pair
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform(Human)
Chongqing University
Curated by ChEMBL
Chongqing University
Curated by ChEMBL
Affinity DataEC50: 67nMAssay Description:Inhibition of PI3K-gamma (unknown origin) after 40 mins by Kinase-Glo assayMore data for this Ligand-Target Pair
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Human)
Chongqing University
Curated by ChEMBL
Chongqing University
Curated by ChEMBL
Affinity DataEC50: 93nMAssay Description:Inhibition of PI3K-delta (unknown origin) after 40 mins by Kinase-Glo assayMore data for this Ligand-Target Pair
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform(Human)
Chongqing University
Curated by ChEMBL
Chongqing University
Curated by ChEMBL
Affinity DataEC50: 15nMAssay Description:Inhibition of PI3Kbeta (unknown origin) after 40 mins by kinase-Glo reagent based luminescence assayMore data for this Ligand-Target Pair
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Human)
Chongqing University
Curated by ChEMBL
Chongqing University
Curated by ChEMBL
Affinity DataEC50: 40nMAssay Description:Inhibition of wild type PI3Kalpha (unknown origin) after 40 mins by kinase-Glo reagent based luminescence assayMore data for this Ligand-Target Pair
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform(Human)
Chongqing University
Curated by ChEMBL
Chongqing University
Curated by ChEMBL
Affinity DataEC50: 67nMAssay Description:Inhibition of PI3Kgamma (unknown origin) after 40 mins by kinase-Glo reagent based luminescence assayMore data for this Ligand-Target Pair
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Human)
Chongqing University
Curated by ChEMBL
Chongqing University
Curated by ChEMBL
Affinity DataEC50: 93nMAssay Description:Inhibition of PI3Kdelta (unknown origin) after 40 mins by kinase-Glo reagent based luminescence assayMore data for this Ligand-Target Pair