BDBM92862 US9284315, BEZ-235::mTOR Inhibitor, BEZ235

SMILES Cn1c2cnc3ccc(cc3c2n(-c2ccc(cc2)C(C)(C)C#N)c1=O)-c1cnc2ccccc2c1

InChI Key InChIKey=JOGKUKXHTYWRGZ-UHFFFAOYSA-N

Data  2 KI  132 IC50  8 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 92862   

LigandPNGBDBM92862(US9284315, BEZ-235 | mTOR Inhibitor, BEZ235)
Affinity DataIC50:  79nMAssay Description:Inhibition of human PI3Kbeta using PIP2 as substrate after 1 hrMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM92862(US9284315, BEZ-235 | mTOR Inhibitor, BEZ235)
Affinity DataIC50:  6nMAssay Description:Inhibition of human PI3Kgamma using PIP2 as substrate after 1 hrMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase mTOR(Human)
Zydus Research Centre

Curated by ChEMBL
LigandPNGBDBM92862(US9284315, BEZ-235 | mTOR Inhibitor, BEZ235)
Affinity DataIC50:  14nMAssay Description:Inhibition of mTOR (unknown origin) assessed as reduction in p70S6K phosphorylationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM92862(US9284315, BEZ-235 | mTOR Inhibitor, BEZ235)
Affinity DataIC50:  5nMAssay Description:Inhibition of human PI3Kalpha using PIP2 as substrate after 1 hrMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM92862(US9284315, BEZ-235 | mTOR Inhibitor, BEZ235)
Affinity DataIC50:  8nMAssay Description:Inhibition of human PI3Kdelta using PIP2 as substrate after 1 hrMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed