BDBM92862 US9284315, BEZ-235::mTOR Inhibitor, BEZ235
SMILES Cn1c2cnc3ccc(cc3c2n(-c2ccc(cc2)C(C)(C)C#N)c1=O)-c1cnc2ccccc2c1
InChI Key InChIKey=JOGKUKXHTYWRGZ-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 5 hits for monomerid = 92862
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform(Human)
Zydus Research Centre
Curated by ChEMBL
Zydus Research Centre
Curated by ChEMBL
Affinity DataIC50: 79nMAssay Description:Inhibition of human PI3Kbeta using PIP2 as substrate after 1 hrMore data for this Ligand-Target Pair
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform(Human)
Zydus Research Centre
Curated by ChEMBL
Zydus Research Centre
Curated by ChEMBL
Affinity DataIC50: 6nMAssay Description:Inhibition of human PI3Kgamma using PIP2 as substrate after 1 hrMore data for this Ligand-Target Pair
Affinity DataIC50: 14nMAssay Description:Inhibition of mTOR (unknown origin) assessed as reduction in p70S6K phosphorylationMore data for this Ligand-Target Pair
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Human)
Zydus Research Centre
Curated by ChEMBL
Zydus Research Centre
Curated by ChEMBL
Affinity DataIC50: 5nMAssay Description:Inhibition of human PI3Kalpha using PIP2 as substrate after 1 hrMore data for this Ligand-Target Pair
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Human)
Zydus Research Centre
Curated by ChEMBL
Zydus Research Centre
Curated by ChEMBL
Affinity DataIC50: 8nMAssay Description:Inhibition of human PI3Kdelta using PIP2 as substrate after 1 hrMore data for this Ligand-Target Pair