BDBM50393642 CHEMBL2158685

SMILES Clc1ccc(cc1)C12CC3CC(CC(C3)(C1)C(=O)NCc1ccncc1)C2

InChI Key InChIKey=CAOTVXGYTWCKQE-UHFFFAOYSA-N

Data  15 KI  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50393642   

TargetSphingosine kinase 2(Homo sapiens (Human))
Virginia Tech

Curated by ChEMBL
LigandPNGBDBM50393642(CHEMBL2158685)
Affinity DataKi:  9.80E+3nMAssay Description:Inhibition of human recombinant SphK2 using NBD-sphingosine as substrate after 2 hrs by HPLC analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine kinase 2(Homo sapiens (Human))
Virginia Tech

Curated by ChEMBL
LigandPNGBDBM50393642(CHEMBL2158685)
Affinity DataKi:  9.80E+3nMAssay Description:Inhibition of human recombinant SphK2 expressed in Sf9 cells assessed as radiolabeled products using 10 uM sphingosine and 10 uM gamma[32P]ATP by liq...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine kinase 2(Homo sapiens (Human))
Virginia Tech

Curated by ChEMBL
LigandPNGBDBM50393642(CHEMBL2158685)
Affinity DataKi:  9.80E+3nMAssay Description:Inhibition of recombinant human N-terminal His-tagged Sphk2 (2 to 593 residues) expressed in Escherichia coli using varying level of sphingosine as s...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine kinase 2(Homo sapiens (Human))
Virginia Tech

Curated by ChEMBL
LigandPNGBDBM50393642(CHEMBL2158685)
Affinity DataKi:  1.00E+4nMAssay Description:Inhibition of SphK2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed