BDBM50240510 CHEMBL898::DIFLUNISAL

SMILES OC(=O)c1cc(ccc1O)-c1ccc(F)cc1F

InChI Key InChIKey=HUPFGZXOMWLGNK-UHFFFAOYSA-N

Data  8 KI  10 IC50  9 Kd  4 EC50

PDB links: 9 PDB IDs match this monomer.

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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50240510   

TargetTransthyretin(Homo sapiens (Human))
University of Toyama

Curated by ChEMBL
LigandPNGBDBM50240510(CHEMBL898 | DIFLUNISAL)
Affinity DataIC50:  1.20E+4nMAssay Description:Inhibition of ANS binding to TTR V30M mutant (unknown origin) expressed in Escherichia coli assessed as BC50 for ANS binding to TTR at 5 uM in presen...More data for this Ligand-Target Pair
TargetTransthyretin(Homo sapiens (Human))
University of Toyama

Curated by ChEMBL
LigandPNGBDBM50240510(CHEMBL898 | DIFLUNISAL)
Affinity DataIC50:  1.20E+4nMAssay Description:Inhibition of ANS binding to TTR V30M mutant (unknown origin) expressed in Escherichia coli assessed as BC50 for ANS binding to TTR at 5 uM in presen...More data for this Ligand-Target Pair
TargetTransthyretin(Homo sapiens (Human))
University of Toyama

Curated by ChEMBL
LigandPNGBDBM50240510(CHEMBL898 | DIFLUNISAL)
Affinity DataKd:  75nMAssay Description:Binding affinity to wild type TTR (unknown origin) expressed in Escherichia coli BL21/DE3 by Circular dichroism spectroscopyMore data for this Ligand-Target Pair
TargetTransthyretin(Homo sapiens (Human))
University of Toyama

Curated by ChEMBL
LigandPNGBDBM50240510(CHEMBL898 | DIFLUNISAL)
Affinity DataKd:  5.60E+3nMAssay Description:Stabilization of TTR V30M mutant (unknown origin) assessed as inhibition of protein-mediated amyloid fibril formationMore data for this Ligand-Target Pair
TargetTransthyretin(Homo sapiens (Human))
University of Toyama

Curated by ChEMBL
LigandPNGBDBM50240510(CHEMBL898 | DIFLUNISAL)
Affinity DataIC50:  6.60E+3nMAssay Description:Inhibition of acid-mediated aggregation of TTR V30M mutant (unknown origin) expressed in Escherichia coli pretreated for 30 mins at pH 7 followed by ...More data for this Ligand-Target Pair
TargetTransthyretin(Homo sapiens (Human))
University of Toyama

Curated by ChEMBL
LigandPNGBDBM50240510(CHEMBL898 | DIFLUNISAL)
Affinity DataIC50:  3.50E+3nMAssay Description:Stabilization of TTR V3OM mutant (unknown origin) assessed as acid-mediated protein aggregation inhibition ratio incubated for 1 week by absorbance m...More data for this Ligand-Target Pair
TargetTransthyretin(Homo sapiens (Human))
University of Toyama

Curated by ChEMBL
LigandPNGBDBM50240510(CHEMBL898 | DIFLUNISAL)
Affinity DataEC50:  5.60E+3nMAssay Description:Inhibition of TTR V30M mutant (unknown origin) expressed in Escherichia coli assessed as inhibition of amyloid fibril formation by fluorescence assayMore data for this Ligand-Target Pair
TargetTransthyretin(Homo sapiens (Human))
University of Toyama

Curated by ChEMBL
LigandPNGBDBM50240510(CHEMBL898 | DIFLUNISAL)
Affinity DataKd:  1.30E+3nMAssay Description:Binding affinity to TTR V30M mutant (unknown origin) by isothermal titration calorimetryMore data for this Ligand-Target Pair