BDBM50387084 BMS-790052::DACLATASVIR

SMILES COC(=O)N[C@@H](C(C)C)C(=O)N1CCC[C@H]1c1nc(c[nH]1)-c1ccc(cc1)-c1ccc(cc1)-c1c[nH]c(n1)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)OC)C(C)C

InChI Key InChIKey=FKRSSPOQAMALKA-CUPIEXAXSA-N

Data  15 IC50  19 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50387084   

TargetNonstructural protein 5A(Hepatitis C virus)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50387084(BMS-790052 | DACLATASVIR)
Affinity DataEC50:  0.0790nMAssay Description:Inhibition of HCV genotype 1a NS5A infected in HuH-7-Luc/Neo-ET cells assessed as reduction in viral replication measured by Luciferase reporter gene...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNonstructural protein 5A(Hepatitis C virus)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50387084(BMS-790052 | DACLATASVIR)
Affinity DataEC50:  0.0320nMAssay Description:Inhibition of NS5A in HCV genotype 1a infected in HuH-Lcu-Neo cells assessed as reduction in viral replication incubated for 48 hrs by luciferase rep...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNonstructural protein 5A(Hepatitis C virus)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50387084(BMS-790052 | DACLATASVIR)
Affinity DataEC50:  52.8nMAssay Description:Inhibition of NS5A in HCV genotype 2a con infected in HuH-Lcu-Neo cells assessed as reduction in viral replication incubated for 48 hrs by luciferase...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNonstructural protein 5A(Hepatitis C virus)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50387084(BMS-790052 | DACLATASVIR)
Affinity DataEC50:  49.4nMAssay Description:Inhibition of NS5A in patient-derived HCV genotype 2a infected in HuH-Lcu-Neo cells assessed as reduction in viral replication incubated for 48 hrs b...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNonstructural protein 5A(Hepatitis C virus)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50387084(BMS-790052 | DACLATASVIR)
Affinity DataEC50:  0.412nMAssay Description:Inhibition of NS5A in HCV genotype 3a con infected in HuH-Lcu-Neo cells assessed as reduction in viral replication incubated for 48 hrs by luciferase...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNonstructural protein 5A(Hepatitis C virus)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50387084(BMS-790052 | DACLATASVIR)
Affinity DataEC50:  0.115nMAssay Description:Inhibition of NS5A in patient-derived HCV genotype 3a infected in HuH-Lcu-Neo cells assessed as reduction in viral replication incubated for 48 hrs b...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNonstructural protein 5A(Hepatitis C virus)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50387084(BMS-790052 | DACLATASVIR)
Affinity DataEC50:  0.00800nMAssay Description:Inhibition of NS5A in HCV genotype 1b infected in HuH-Lcu-Neo cells assessed as reduction in viral replication incubated for 48 hrs by luciferase rep...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNonstructural protein 5A(Hepatitis C virus)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50387084(BMS-790052 | DACLATASVIR)
Affinity DataEC50:  0.0320nMAssay Description:Inhibition of HCV genotype 1b NS5A infected in HuH-7-Luc/Neo-ET cells assessed as reduction in viral replication measured by Luciferase reporter gene...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed