BDBM176061 US10047103, 94::US9688695, 94

SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3nc(sc3C)N3CCOCC3)cc(OC)cc2o1

InChI Key InChIKey=MINMDCMSHDBHKG-UHFFFAOYSA-N

Data  16 IC50  2 Kd  4 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 176061   

TargetProteinase-activated receptor 4(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM176061(US10047103, 94 | US9688695, 94)
Affinity DataIC50:  9.70nMAssay Description:Antagonist activity at PAR4 in human platelet-rich plasma assessed as inhibition of PAR4 AP AYPGKF-NH2-induced platelet aggregation by photo-turbidim...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProteinase-activated receptor 4(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM176061(US10047103, 94 | US9688695, 94)
Affinity DataIC50:  0.700nMAssay Description:Antagonist activity at human PAR4 expressed in Ga15-HEK293 cells assessed as reduction in PAR4 AP AYPGKF-NH2-induced cytosolic calcium incubated for ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProteinase-activated receptor 1(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM176061(US10047103, 94 | US9688695, 94)
Affinity DataIC50: >3.16E+3nMAssay Description:Antagonist activity at human PAR1 expressed in Ga15-HEK293 cells assessed as reduction in PAR1 AP SFFLRR-NH2-induced cytosolic calcium incubated for ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProteinase-activated receptor 2(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM176061(US10047103, 94 | US9688695, 94)
Affinity DataIC50: >1.00E+3nMAssay Description:Antagonist activity at human PAR2 expressed in Ga15-HEK293 cells assessed as reduction in PAR2 AP 2-furoyl-LIGRLO-NH2-induced cytosolic calcium incub...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed