BDBM50121205 CHEBI:18295::Histamine
SMILES NCCc1c[nH]cn1
InChI Key InChIKey=NTYJJOPFIAHURM-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 52 hits for monomerid = 50121205
Affinity DataKi: 10nMAssay Description:Displacement of [3H]-UR-PI294 from Galphai2/Gbeta1gamma2-coupled human recombinant H3R expressed in baculovirus infected Sf9 insect cell membranes co...More data for this Ligand-Target Pair
Affinity DataKi: 10nMAssay Description:Displacement of [3H]-N-alpha-methylhistamine from human recombinant H3R expressed in human SK-N-MC cell membranesMore data for this Ligand-Target Pair
Affinity DataKi: 13nMAssay Description:Displacement of [3H]-histamine from Galphai2/Gbeta1gamma2-coupled human recombinant H4R expressed in baculovirus infected Sf9 insect cell membranes m...More data for this Ligand-Target Pair
3D Structure (crystal)Affinity DataKi: 19nMAssay Description:Displacement of [3H]-N-alpha-methylhistamine from Galphai2/Gbeta1gamma2-coupled human recombinant H3R expressed in baculovirus infected Sf9 insect ce...More data for this Ligand-Target Pair
Affinity DataKi: 25nMAssay Description:Displacement of [3H]histamine from human histamine H4 receptor expressed in sf9 insect cell membranes co-expressing Galphai2/Gbeta1gamma2 incubated f...More data for this Ligand-Target Pair
Affinity DataKi: 25nMAssay Description:Displacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 an...More data for this Ligand-Target Pair
Affinity DataKi: 26nMAssay Description:Displacement of [3H]UR-P129 from human histamine H3 receptor expressed in sf9 insect cell membranes co-expressing Galphai2/Gbeta1gamma2 incubated for...More data for this Ligand-Target Pair
Affinity DataKi: 26nMAssay Description:Displacement of [3H]Nalpha-methylhistamine from human histamine H3 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing ...More data for this Ligand-Target Pair
Affinity DataKi: 63nMAssay Description:Displacement of [3H]-histamine from Galphai2/Gbeta1gamma2-coupled human recombinant H4R expressed in baculovirus infected Sf9 insect cell membranesMore data for this Ligand-Target Pair
Affinity DataKi: 63nMAssay Description:Displacement of UR-DEBa176 from human recombinant H4R expressed in HEK293T-SF-His6-CRE-Luc cellsMore data for this Ligand-Target Pair
Affinity DataKi: 63nMAssay Description:Displacement of [3H]-histamine from human recombinant H4R expressed in HEK293T cell homogenatesMore data for this Ligand-Target Pair
Affinity DataKi: 63nMAssay Description:Displacement of [3H]-histamine from human recombinant H4R stably expressed in human SK-N-MC cell membranesMore data for this Ligand-Target Pair
Affinity DataKi: 63nMAssay Description:Displacement of [3H]-histamine from human recombinant H4R stably expressed in human SK-N-MC cell homogenatesMore data for this Ligand-Target Pair
Affinity DataKi: 63nMAssay Description:Displacement of [3H]-UR-PI294 from Galphai2/Gbeta1gamma2-coupled human recombinant H4R expressed in baculovirus infected Sf9 insect cell membranes co...More data for this Ligand-Target Pair
Affinity DataKi: 158nMAssay Description:Displacement of clobenpropit-BODIPY-630/650 from recombinant human NLuc-fused H4R expressed in HEK293T cells by Nano-BRET assayMore data for this Ligand-Target Pair
Affinity DataKi: 219nMAssay Description:Inhibition of UR-DEBa242 binding to human recombinant NLuc/GPCR-fused H4R expressed in HEK293T cells measured after 30 mins by furimazine substrate b...More data for this Ligand-Target Pair
Affinity DataKi: 263nMAssay Description:Displacement of [3H]UR-DE257 from Gsalphas-coupled human H2R expressed in Sf9 cell membranes by competitive binding assayMore data for this Ligand-Target Pair
Affinity DataKi: 263nMAssay Description:Displacement of [3H]UR-DE257 from human histamine H2 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RG-Salpha S in...More data for this Ligand-Target Pair
Affinity DataKi: 263nMAssay Description:Displacement of [3H]UR-DE257 from human histamine H2 receptor expressed in sf9 insect cell membranes co-expressing GSalphaS incubated for 60 mins by ...More data for this Ligand-Target Pair
Affinity DataKi: 316nMAssay Description:Inhibition of UR-DEBa242 binding to human recombinant NLuc/GPCR-fused H3R expressed in HEK293T cells measured after 30 mins by furimazine substrate b...More data for this Ligand-Target Pair
Affinity DataKi: 501nMAssay Description:Displacement of clobenpropit-BODIPY-630/650 from recombinant human NLuc-fused H3R expressed in HEK293T cells by Nano-BRET assayMore data for this Ligand-Target Pair
Affinity DataKi: 501nMAssay Description:Displacement of UR-DEBa176 from mouse recombinant H4R expressed in HEK293T-SF-His6-CRE-Luc cellsMore data for this Ligand-Target Pair
Affinity DataKi: 501nMAssay Description:Binding affinity in Nluc-hH3R assessed in HEK293T cells by NanoBRET binding assayMore data for this Ligand-Target Pair
Affinity DataKi: 589nMAssay Description:Binding affinity in Nluc-hH3R assessed in HEK293 cells by NanoBRET binding assayMore data for this Ligand-Target Pair
Affinity DataKi: 2.14E+3nMAssay Description:Inhibition of UR-DEBa242 binding to mouse recombinant NLuc/GPCR-fused H4R expressed in HEK293T cells measured after 30 mins by furimazine substrate b...More data for this Ligand-Target Pair
Affinity DataKi: 2.40E+3nMAssay Description:Displacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incuba...More data for this Ligand-Target Pair
Affinity DataKi: 2.40E+3nMAssay Description:Displacement of [3H]mepyramine from human histamine H1 receptor expressed in sf9 insect cell membranes co-expressing RGS4 incubated for 60 mins by mi...More data for this Ligand-Target Pair
Affinity DataEC50: 11nMAssay Description:Agonist activity at human histamine H4 receptor expressed in sf9 cell membrane co-expressing mammalian Galphai2 and Gbeta1gamma2 incubated for 90 min...More data for this Ligand-Target Pair
Affinity DataEC50: 13nMAssay Description:Agonist activity at human histamine H3 receptor expressed in sf9 cell membrane co-expressing mammalian Galphai2 and Gbeta1gamma2 incubated for 90 min...More data for this Ligand-Target Pair
Affinity DataEC50: 190nMAssay Description:Agonist activity at human histamine H1 receptor expressed in sf9 cell membrane co-expressing RGS4 or RGS9 assessed as increase in 32Pi level incubate...More data for this Ligand-Target Pair
Affinity DataEC50: 13nMAssay Description:Agonist activity at human SF-His6-tagged histamine H4 receptor expressed in HEK293 cells assessed as inhibition of forskolin-stimulated response incu...More data for this Ligand-Target Pair
Affinity DataEC50: 94nMAssay Description:Agonist activity at mouse SF-His6-tagged histamine H4 receptor expressed in HEK293 cells assessed as inhibition of forskolin-stimulated response incu...More data for this Ligand-Target Pair
Affinity DataEC50: 3.30nMAssay Description:Agonist activity at human H3R expressed in HEK293T-SP-FLAG-hH3R-CRE-CBR cells incubated for 5 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
Affinity DataEC50: 17nMAssay Description:Agonist activity at human H4R expressed in HEK293-SF-hH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
Affinity DataEC50: 34nMAssay Description:Agonist activity at human H4R expressed in HEK293 cells co-expressing ELucC/ELucN-beta-arrestin2 assessed as induction of beta-arrestin recruitment b...More data for this Ligand-Target Pair
Affinity DataEC50: 87nMAssay Description:Agonist activity at mouse H4R expressed in HEK293-SF-mH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
Affinity DataEC50: 2.34E+3nMAssay Description:Agonist activity at mouse H4R expressed in HEK293 cells co-expressing ELucC/ELucN-beta-arrestin2 assessed as induction of beta-arrestin recruitment b...More data for this Ligand-Target Pair
TargetHistamine H2 receptor(Cavia porcellus (domestic guinea pig))
University Of Regensburg
Curated by ChEMBL
University Of Regensburg
Curated by ChEMBL
Affinity DataEC50: 692nMAssay Description:Agonist activity at guinea pig right atrium histamine H2 receptor assessed as increase in heart rate incubated for 30 mins in presence of cimetidineMore data for this Ligand-Target Pair
Affinity DataEC50: 977nMAssay Description:Agonist activity at human histamine receptor expressed in sf9 insect cell membranes co-exprssing GsalphaS incubated for 90 mins [35S]GTPgammaS bindin...More data for this Ligand-Target Pair
Affinity DataEC50: 3.80E+3nMAssay Description:Agonist activity at human histamine H2 receptor expressed in HEK293T cells co-expressing ELucC by beta arrestin2 recruitment assayMore data for this Ligand-Target Pair
Affinity DataKd: 12nMAssay Description:Displacement of [3H]UR-DE257 from human histamine H2 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RG-Salpha S in...More data for this Ligand-Target Pair
Affinity DataKd: 3nMAssay Description:Displacement of [3H]Nalpha-methylhistamine from human histamine H3 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing ...More data for this Ligand-Target Pair
Affinity DataKd: 16nMAssay Description:Displacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 an...More data for this Ligand-Target Pair
Affinity DataEC50: 3.80E+3nMAssay Description:Agonist activity at human histamine H2 receptor stably expressed in HEK293T cells co-expressing ARRB2 incubated for 60 mins by beta-arrestin2 recruit...More data for this Ligand-Target Pair
Affinity DataEC50: 115nMAssay Description:Agonist activity at human histamine H2 receptor stably expressed in HEK293T cells co-expressing NlucN-mGs/hH2R-NlucC assessed as induction of mini-Gi...More data for this Ligand-Target Pair
TargetHistamine H2 receptor(Cavia porcellus (domestic guinea pig))
University Of Regensburg
Curated by ChEMBL
University Of Regensburg
Curated by ChEMBL
Affinity DataEC50: 251nMAssay Description:Agonist activity at guinea pig histamine H2 receptor stably transfected in HEK293T cells co-expressing NlucN-mGs/gpH2R-NlucC by mini-G protein recrui...More data for this Ligand-Target Pair
TargetHistamine H2 receptor(Cavia porcellus (domestic guinea pig))
University Of Regensburg
Curated by ChEMBL
University Of Regensburg
Curated by ChEMBL
Affinity DataEC50: 692nMAssay Description:Agonist activity at histamine H2 receptor in spontaneous beating guinea pig right atrium assessed as increase in heart beatMore data for this Ligand-Target Pair
Affinity DataEC50: 115nMAssay Description:Agonist activity at human H2 receptor expressed in HEK293T-ARRB2 cells assessed as stimulation of beta-arrestin 2 recruitmentMore data for this Ligand-Target Pair
Affinity DataEC50: 1.41E+3nMAssay Description:Agonist activity at human H2 receptor expressed in Sf9 cell membranes co-exprssing GsalphaS assessed as stimulation of [35S]GTPgammaS binding incubat...More data for this Ligand-Target Pair
Affinity DataEC50: 3.80E+3nMAssay Description:Agonist activity at NlucN/mini-Gi protein-fused human H2R stably expressed in HEK293T cells assessed as induction of mini-Gi protein recruitment usin...More data for this Ligand-Target Pair