BDBM50507492 Loxo-195::Selitrectinib::US10966985, Compound 33-B

SMILES C[C@@H]1CCc2ncc(F)cc2[C@H]2CCCN2c2ccn3ncc(C(=O)N1)c3n2

InChI Key InChIKey=OEBIHOVSAMBXIB-SJKOYZFVSA-N

Data  44 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50507492   

TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Jinan University

Curated by ChEMBL
LigandPNGBDBM50507492(Loxo-195 | Selitrectinib | US10966985, Compound 33...)
Affinity DataIC50:  3nMAssay Description:Inhibition of N-terminal hexahistidine tagged TRKA (485 to 795 residues) (unknown origin) expressed in Sf9 cells using Ser/Thr 06 peptide as substrat...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetNT-3 growth factor receptor(Homo sapiens (Human))
Jinan University

Curated by ChEMBL
LigandPNGBDBM50507492(Loxo-195 | Selitrectinib | US10966985, Compound 33...)
Affinity DataIC50:  2.40nMAssay Description:Inhibition of TRKC (unknown origin) using Ser/Thr 06 peptide as substrate incubated for 1 hr in presence of 50 uM ATP by FRET based Z'-Lyte assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Jinan University

Curated by ChEMBL
LigandPNGBDBM50507492(Loxo-195 | Selitrectinib | US10966985, Compound 33...)
Affinity DataIC50:  300nMAssay Description:Inhibition of TRKA G667C mutant (unknown origin) using Ser/Thr 06 peptide as substrate incubated for 1 hr in presence of 400 uM ATP by FRET based Z'-...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Jinan University

Curated by ChEMBL
LigandPNGBDBM50507492(Loxo-195 | Selitrectinib | US10966985, Compound 33...)
Affinity DataIC50:  2.10nMAssay Description:Inhibition of TRKA G595R mutant (unknown origin) by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails PubMed