BDBM109086 US10793535, Cmpd ID 727::US8604016, 670::US9938267, Cmpd ID 670

SMILES FC(F)(F)Oc1cccc(CC(=O)Nc2ccc(CCCCc3nnc(NC(=O)Cc4ccccn4)s3)nn2)c1

InChI Key InChIKey=PRAAPINBUWJLGA-UHFFFAOYSA-N

Data  24 IC50  4 Kd

PDB links: 2 PDB IDs match this monomer.

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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 109086   

TargetGlutaminase kidney isoform, mitochondrial(Mus musculus)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM109086(US10793535, Cmpd ID 727 | US8604016, 670 | US99382...)
Affinity DataIC50:  20nMAssay Description:Inhibition of GLS1 in mouse kidney assessed as inhibition of glutamate production using glutamine as substrate incubated for 1 hr by coupled assayMore data for this Ligand-Target Pair
TargetGlutaminase kidney isoform, mitochondrial(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM109086(US10793535, Cmpd ID 727 | US8604016, 670 | US99382...)
Affinity DataIC50:  31nMAssay Description:Allosteric inhibition of human GLS1 using glutamine as substrate incubated for 60 mins by NADH/NADPH-based absorbance analysisMore data for this Ligand-Target Pair
TargetGlutaminase kidney isoform, mitochondrial(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM109086(US10793535, Cmpd ID 727 | US8604016, 670 | US99382...)
Affinity DataKd:  106nMAssay Description:Binding affinity to human GLS1 assessed as dissociation constant by surface plasmon resonance analysisMore data for this Ligand-Target Pair
TargetGlutaminase kidney isoform, mitochondrial(Mus musculus)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM109086(US10793535, Cmpd ID 727 | US8604016, 670 | US99382...)
Affinity DataIC50:  20nMAssay Description:Inhibition of GLS1 in mouse brain assessed as inhibition of glutamate production using glutamine as substrate incubated for 1 hr by coupled assayMore data for this Ligand-Target Pair