BDBM50021954 (2S,5R)-3,3-Dimethyl-4,4,7-trioxo-4lambda*6*-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid::(S)-3,3-Dimethyl-7-(R)-oxo-4,4-dioxo-4lambda*6*-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid::3,3-Dimethyl-4,4,7-trioxo-4lambda*6*-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid::3,3-Dimethyl-4,4,7-trioxo-4lambda*6*-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid (Sulbactam)::CHEMBL403::CP-45,899::SULBACTAM::UNASYN::US20230322715, Compound ALK-09::US9120808, Sulbactam sodium salt

SMILES CC1(C)[C@@H](N2[C@@H](CC2=O)S1(=O)=O)C(O)=O

InChI Key InChIKey=FKENQMMABCRJMK-RITPCOANSA-N

Data  3 KI  54 IC50

PDB links: 3 PDB IDs match this monomer.

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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50021954   

TargetBeta-lactamase 1(Bacillus cereus)
TBA

Curated by ChEMBL
LigandPNGBDBM50021954((2S,5R)-3,3-Dimethyl-4,4,7-trioxo-4lambda*6*-thia-...)
Affinity DataIC50:  2.50E+4nMAssay Description:Inhibition of Beta-lactamase of Bacillus cereus (class A enzyme) without preincubationMore data for this Ligand-Target Pair
In DepthDetails Article
TargetBeta-lactamase TEM(Escherichia coli)
TBA

Curated by ChEMBL
LigandPNGBDBM50021954((2S,5R)-3,3-Dimethyl-4,4,7-trioxo-4lambda*6*-thia-...)
Affinity DataIC50:  800nMAssay Description:Compound was evaluated for beta-lactamase inhibition activity of Escherichia coli after 15 min of preincubation with the enzyme at 37 degree CMore data for this Ligand-Target Pair
In DepthDetails Article
TargetBeta-lactamase(Enterobacter cloacae)
TBA

Curated by ChEMBL
LigandPNGBDBM50021954((2S,5R)-3,3-Dimethyl-4,4,7-trioxo-4lambda*6*-thia-...)
Affinity DataIC50:  1.00E+3nMAssay Description:Compound was evaluated for beta-lactamase inhibition activity of Escherichia cloacae after 15 min of preincubation with the enzyme at 37 degree CMore data for this Ligand-Target Pair
In DepthDetails Article
TargetBeta-lactamase OXA-1(Escherichia coli)
TBA

Curated by ChEMBL
LigandPNGBDBM50021954((2S,5R)-3,3-Dimethyl-4,4,7-trioxo-4lambda*6*-thia-...)
Affinity DataIC50:  2.20E+4nMAssay Description:Inhibitory activity against Beta-lactamase type OXA1 (penicillinase) from E. coli OXA1 using ampicillin (40 uM) as a substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-lactamase TEM(Escherichia coli)
TBA

Curated by ChEMBL
LigandPNGBDBM50021954((2S,5R)-3,3-Dimethyl-4,4,7-trioxo-4lambda*6*-thia-...)
Affinity DataIC50:  3.20E+5nMAssay Description:Inhibitory activity against Beta-lactamase type TEM2 (penicillinase) from E. coli TEM2 using penicillin G (40 uM) as a substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-lactamase(Staphylococcus aureus)
TBA

Curated by ChEMBL
LigandPNGBDBM50021954((2S,5R)-3,3-Dimethyl-4,4,7-trioxo-4lambda*6*-thia-...)
Affinity DataIC50:  6.50E+3nMAssay Description:Inhibitory activity against Penicillinase from Staphylococcus aureus TH-14 using piperacillin (40 uM) as a substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-lactamase 1(Bacillus cereus)
TBA

Curated by ChEMBL
LigandPNGBDBM50021954((2S,5R)-3,3-Dimethyl-4,4,7-trioxo-4lambda*6*-thia-...)
Affinity DataIC50:  2.50E+4nMAssay Description:Inhibition of Beta-lactamase of Bacillus cereus (class A enzyme) without preincubationMore data for this Ligand-Target Pair
In DepthDetails Article
TargetBeta-lactamase TEM(Escherichia coli)
TBA

Curated by ChEMBL
LigandPNGBDBM50021954((2S,5R)-3,3-Dimethyl-4,4,7-trioxo-4lambda*6*-thia-...)
Affinity DataIC50:  1.00E+4nMAssay Description:Inhibitory activity against Beta-lactamase type TEM2 (penicillinase) from E. coli TEM2 using penicillin G (40 uM) as a substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed