BDBM12915 2-(4-Morpholinyl)-8-phenyl-4H-1-benzopyran-4-one::2-(morpholin-4-yl)-8-phenyl-4H-chromen-4-one::CHEMBL98350::LY294002::US10308662, Compound LY294002::US9505780, LY294002

SMILES O=c1cc(oc2c(cccc12)-c1ccccc1)N1CCOCC1

InChI Key InChIKey=CZQHHVNHHHRRDU-UHFFFAOYSA-N

Data  8 KI  148 IC50  1 Kd

PDB links: 5 PDB IDs match this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 12915   

TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform(Homo sapiens (Human))
The University Of Sydney

Curated by ChEMBL
LigandPNGBDBM12915(2-(4-Morpholinyl)-8-phenyl-4H-1-benzopyran-4-one |...)
Affinity DataIC50:  420nMAssay Description:Inhibition of immobilized N-LY294002 bead binding to PI3Kbeta (unknown origin) expressed in HEK293T cells incubated for 1 hr by LC-MS/MS analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Homo sapiens (Human))
The University Of Sydney

Curated by ChEMBL
LigandPNGBDBM12915(2-(4-Morpholinyl)-8-phenyl-4H-1-benzopyran-4-one |...)
Affinity DataIC50:  1.53E+3nMAssay Description:Inhibition of immobilized N-LY294002 bead binding to PI3Kdelta (unknown origin) expressed in HEK293T cells incubated for 1 hr by LC-MS/MS analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Homo sapiens (Human))
The University Of Sydney

Curated by ChEMBL
LigandPNGBDBM12915(2-(4-Morpholinyl)-8-phenyl-4H-1-benzopyran-4-one |...)
Affinity DataIC50:  2.37E+3nMAssay Description:Inhibition of immobilized N-LY294002 bead binding to PI3Kalpha (unknown origin) expressed in HEK293T cells incubated for 1 hr by LC-MS/MS analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBromodomain-containing protein 4(Homo sapiens (Human))
The University Of Sydney

Curated by ChEMBL
LigandPNGBDBM12915(2-(4-Morpholinyl)-8-phenyl-4H-1-benzopyran-4-one |...)
Affinity DataIC50:  1.24E+4nMAssay Description:Inhibition of immobilized N-LY294002 bead binding to C-terminal Flag-tagged BRD4 (unknown origin) expressed in HEK293T cell nuclear extract incubated...More data for this Ligand-Target Pair
TargetBromodomain-containing protein 3(Homo sapiens (Human))
The University Of Sydney

Curated by ChEMBL
LigandPNGBDBM12915(2-(4-Morpholinyl)-8-phenyl-4H-1-benzopyran-4-one |...)
Affinity DataIC50:  1.37E+4nMAssay Description:Inhibition of immobilized N-LY294002 bead binding to BRD3 (unknown origin) expressed in HEK293T cell nuclear extract incubated for 1 hr by LC-MS/MS a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBromodomain-containing protein 2(Homo sapiens (Human))
The University Of Sydney

Curated by ChEMBL
LigandPNGBDBM12915(2-(4-Morpholinyl)-8-phenyl-4H-1-benzopyran-4-one |...)
Affinity DataIC50:  1.03E+4nMAssay Description:Inhibition of immobilized N-LY294002 bead binding to BRD2 (unknown origin) expressed in HEK293T cell nuclear extract incubated for 1 hr by LC-MS/MS a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed