BindingDB BDBM3149 2-{[2,6-dihydroxy-4-({[(3R,4R)-3-[(4-hydroxybenzene)amido]azepan-4-yl]oxy}carbonyl)phenyl]carbonyl}-3-hydroxybenzoic acid::Acyclic Balanol Analog (-)-1::Balanol analog 1::Balanol, 1::CHEMBL60254

BDBM3149 2-{[2,6-dihydroxy-4-({[(3R,4R)-3-[(4-hydroxybenzene)amido]azepan-4-yl]oxy}carbonyl)phenyl]carbonyl}-3-hydroxybenzoic acid::Acyclic Balanol Analog (-)-1::Balanol analog 1::Balanol, 1::CHEMBL60254

SMILES OC(=O)c1cccc(O)c1C(=O)c1c(O)cc(cc1O)C(=O)O[C@@H]1CCCNC[C@H]1NC(=O)c1ccc(O)cc1

InChI Key InChIKey=XYUFCXJZFZPEJD-XMSQKQJNSA-N

Data 2 KI 108 IC50 4 Kd

PDB links: 1 PDB ID matches this monomer.

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 28 hits for monomerid = 3149

Protein kinase C alpha type(Homo sapiens (Human))
Sphinx Laboratories

PNG

BDBM3149(2-{[2,6-dihydroxy-4-({[(3R,4R)-3-[(4-hydroxybenzen...)

IC50: 74nMpH: 7.5 T: 2°CAssay Description:PKC was assayed by quantitating the incorporation of 32P from [gamma-32P]ATP into histone type IIIs.More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
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Protein kinase C beta type(Homo sapiens (Human))
Sphinx Laboratories

PNG

BDBM3149(2-{[2,6-dihydroxy-4-({[(3R,4R)-3-[(4-hydroxybenzen...)

IC50: 32nMpH: 7.5 T: 2°CAssay Description:PKC was assayed by quantitating the incorporation of 32P from [gamma-32P]ATP into histone type IIIs.More data for this Ligand-Target Pair

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Protein kinase C beta type(Homo sapiens (Human))
Sphinx Laboratories

PNG

BDBM3149(2-{[2,6-dihydroxy-4-({[(3R,4R)-3-[(4-hydroxybenzen...)

IC50: 44nMpH: 7.5 T: 2°CAssay Description:PKC was assayed by quantitating the incorporation of 32P from [gamma-32P]ATP into histone type IIIs.More data for this Ligand-Target Pair

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Protein kinase C gamma type(Homo sapiens (Human))
Sphinx Laboratories

PNG

BDBM3149(2-{[2,6-dihydroxy-4-({[(3R,4R)-3-[(4-hydroxybenzen...)

IC50: 34nMpH: 7.5 T: 2°CAssay Description:PKC was assayed by quantitating the incorporation of 32P from [gamma-32P]ATP into histone type IIIs.More data for this Ligand-Target Pair

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Protein kinase C delta type(Homo sapiens (Human))
Sphinx Laboratories

PNG

BDBM3149(2-{[2,6-dihydroxy-4-({[(3R,4R)-3-[(4-hydroxybenzen...)

IC50: 32nMAssay Description:PKC was assayed by quantitating the incorporation of 32P from [gamma-32P]ATP into histone type IIIs.More data for this Ligand-Target Pair

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Protein kinase C epsilon type(Homo sapiens (Human))
Sphinx Laboratories

PNG

BDBM3149(2-{[2,6-dihydroxy-4-({[(3R,4R)-3-[(4-hydroxybenzen...)

IC50: 49nMAssay Description:PKC was assayed by quantitating the incorporation of 32P from [gamma-32P]ATP into histone type IIIs.More data for this Ligand-Target Pair

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Protein kinase C eta type(Homo sapiens (Human))
Sphinx Laboratories

PNG

BDBM3149(2-{[2,6-dihydroxy-4-({[(3R,4R)-3-[(4-hydroxybenzen...)

IC50: 22nMAssay Description:PKC was assayed by quantitating the incorporation of 32P from [gamma-32P]ATP into histone type IIIs.More data for this Ligand-Target Pair

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Protein kinase C zeta type(Homo sapiens (Human))
Sphinx Laboratories

PNG

BDBM3149(2-{[2,6-dihydroxy-4-({[(3R,4R)-3-[(4-hydroxybenzen...)

IC50: 3.50E+3nMAssay Description:PKC was assayed by quantitating the incorporation of 32P from [gamma-32P]ATP into histone type IIIs.More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
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cAMP-dependent protein kinase catalytic subunit alpha(Bos taurus (bovine))
Sphinx Laboratories

PNG

BDBM3149(2-{[2,6-dihydroxy-4-({[(3R,4R)-3-[(4-hydroxybenzen...)

IC50: 60nMAssay Description:The activity of PKA, activated by cAMP, is measured by its ability to transfer phosphate from [gamma-32P]ATP to histone.More data for this Ligand-Target Pair

PDB
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Protein kinase C alpha type(Homo sapiens (Human))
Sphinx Laboratories

PNG

BDBM3149(2-{[2,6-dihydroxy-4-({[(3R,4R)-3-[(4-hydroxybenzen...)

IC50: 30nMAssay Description:PKC was assayed by quantitating the incorporation of 32P from [gamma-32P]ATP into histone type IIIs.More data for this Ligand-Target Pair

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Protein kinase C beta type(Homo sapiens (Human))
Sphinx Laboratories

PNG

BDBM3149(2-{[2,6-dihydroxy-4-({[(3R,4R)-3-[(4-hydroxybenzen...)

IC50: 10nMAssay Description:PKC was assayed by quantitating the incorporation of 32P from [gamma-32P]ATP into histone type IIIs.More data for this Ligand-Target Pair

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Protein kinase C beta type(Homo sapiens (Human))
Sphinx Laboratories

PNG

BDBM3149(2-{[2,6-dihydroxy-4-({[(3R,4R)-3-[(4-hydroxybenzen...)

IC50: 10nMAssay Description:PKC was assayed by quantitating the incorporation of 32P from [gamma-32P]ATP into histone type IIIs.More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
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Protein kinase C gamma type(Homo sapiens (Human))
Sphinx Laboratories

PNG

BDBM3149(2-{[2,6-dihydroxy-4-({[(3R,4R)-3-[(4-hydroxybenzen...)

IC50: 10nMAssay Description:PKC was assayed by quantitating the incorporation of 32P from [gamma-32P]ATP into histone type IIIs.More data for this Ligand-Target Pair

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Protein kinase C delta type(Homo sapiens (Human))
Sphinx Laboratories

PNG

BDBM3149(2-{[2,6-dihydroxy-4-({[(3R,4R)-3-[(4-hydroxybenzen...)

IC50: 20nMAssay Description:PKC was assayed by quantitating the incorporation of 32P from [gamma-32P]ATP into histone type IIIs.More data for this Ligand-Target Pair

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cAMP-dependent protein kinase catalytic subunit alpha(Bos taurus (bovine))
Sphinx Laboratories

PNG

BDBM3149(2-{[2,6-dihydroxy-4-({[(3R,4R)-3-[(4-hydroxybenzen...)

IC50: 40nMAssay Description:The activity of PKA, activated by cAMP, is measured by its ability to transfer phosphate from [gamma-32P]ATP to histone.More data for this Ligand-Target Pair

PDB
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Protein kinase C epsilon type(Homo sapiens (Human))
Sphinx Laboratories

PNG

BDBM3149(2-{[2,6-dihydroxy-4-({[(3R,4R)-3-[(4-hydroxybenzen...)

IC50: 20nMAssay Description:PKC was assayed by quantitating the incorporation of 32P from [gamma-32P]ATP into histone type IIIs.More data for this Ligand-Target Pair

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Protein kinase C eta type(Homo sapiens (Human))
Sphinx Laboratories

PNG

BDBM3149(2-{[2,6-dihydroxy-4-({[(3R,4R)-3-[(4-hydroxybenzen...)

IC50: 3nMAssay Description:PKC was assayed by quantitating the incorporation of 32P from [gamma-32P]ATP into histone type IIIs.More data for this Ligand-Target Pair

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Protein kinase C alpha type(Homo sapiens (Human))
Sphinx Laboratories

PNG

BDBM3149(2-{[2,6-dihydroxy-4-({[(3R,4R)-3-[(4-hydroxybenzen...)

IC50: 67nMAssay Description:PKC was assayed by quantitating the incorporation of 32P from [gamma-32P]ATP into histone type IIIs.More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
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Protein kinase C beta type(Homo sapiens (Human))
Sphinx Laboratories

PNG

BDBM3149(2-{[2,6-dihydroxy-4-({[(3R,4R)-3-[(4-hydroxybenzen...)

IC50: 30nMAssay Description:PKC was assayed by quantitating the incorporation of 32P from [gamma-32P]ATP into histone type IIIs.More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
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Protein kinase C epsilon type(Homo sapiens (Human))
Sphinx Laboratories

PNG

BDBM3149(2-{[2,6-dihydroxy-4-({[(3R,4R)-3-[(4-hydroxybenzen...)

IC50: 38nMAssay Description:PKC was assayed by quantitating the incorporation of 32P from [gamma-32P]ATP into histone type IIIs.More data for this Ligand-Target Pair

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Protein kinase C delta type(Homo sapiens (Human))
Sphinx Laboratories

PNG

BDBM3149(2-{[2,6-dihydroxy-4-({[(3R,4R)-3-[(4-hydroxybenzen...)

IC50: 32nMAssay Description:Inhibition of Protein kinase C deltaMore data for this Ligand-Target Pair

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Protein kinase C beta type(Homo sapiens (Human))
Sphinx Laboratories

PNG

BDBM3149(2-{[2,6-dihydroxy-4-({[(3R,4R)-3-[(4-hydroxybenzen...)

IC50: 44nMAssay Description:Inhibition of Protein kinase C beta 2More data for this Ligand-Target Pair

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Protein kinase C eta type(Homo sapiens (Human))
Sphinx Laboratories

PNG

BDBM3149(2-{[2,6-dihydroxy-4-({[(3R,4R)-3-[(4-hydroxybenzen...)

IC50: 22nMAssay Description:Inhibition of Protein kinase C etaMore data for this Ligand-Target Pair

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Protein kinase C zeta type(Homo sapiens (Human))
Sphinx Laboratories

PNG

BDBM3149(2-{[2,6-dihydroxy-4-({[(3R,4R)-3-[(4-hydroxybenzen...)

IC50: 3.50E+3nMAssay Description:Inhibition of Protein kinase C zetaMore data for this Ligand-Target Pair

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Protein kinase C alpha type(Homo sapiens (Human))
Sphinx Laboratories

PNG

BDBM3149(2-{[2,6-dihydroxy-4-({[(3R,4R)-3-[(4-hydroxybenzen...)

IC50: 74nMAssay Description:Inhibition of Protein kinase C alphaMore data for this Ligand-Target Pair

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Protein kinase C epsilon type(Homo sapiens (Human))
Sphinx Laboratories

PNG

BDBM3149(2-{[2,6-dihydroxy-4-({[(3R,4R)-3-[(4-hydroxybenzen...)

IC50: 44nMAssay Description:Inhibition of Protein kinase C epsilonMore data for this Ligand-Target Pair

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cAMP-dependent protein kinase catalytic subunit alpha/beta/gamma(Homo sapiens (Human))
Sphinx Laboratories

PNG

BDBM3149(2-{[2,6-dihydroxy-4-({[(3R,4R)-3-[(4-hydroxybenzen...)

IC50: 60nMAssay Description:Inhibition of Protein kinase C epsilonMore data for this Ligand-Target Pair

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Protein kinase C gamma type(Homo sapiens (Human))
Sphinx Laboratories

PNG

BDBM3149(2-{[2,6-dihydroxy-4-({[(3R,4R)-3-[(4-hydroxybenzen...)

IC50: 34nMAssay Description:Inhibition Protein kinase C gammaMore data for this Ligand-Target Pair

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Filter my 114 hits

Targets 19▿
- Protein kinase C beta type 25
- Protein kinase C alpha type 15
- Protein kinase C epsilon type 13
- Protein kinase C eta type 13
- Protein kinase C delta type 12
- Protein kinase C gamma type 11
- Protein kinase C zeta type 6
- cAMP-dependent protein kinase catalytic subunit alpha 4
- cAMP-dependent protein kinase catalytic subunit alpha/beta/gamma 3
- G protein-coupled receptor kinase 5 2
- Rhodopsin kinase GRK1 2
- cAMP-dependent protein kinase catalytic subunit gamma 1
- cGMP-dependent protein kinase 1 1
- Rhodopsin kinase GRK7 1
- Beta-adrenergic receptor kinase 2 1
- G protein-coupled receptor kinase 4 1
- Beta-adrenergic receptor kinase 1 1
- G protein-coupled receptor kinase 6 1
- cAMP-dependent protein kinase 1
- ...
Publications 15▿
- Bioorg Med Chem Lett 6: 973-978 (1996) 16
- Bioorg Med Chem Lett 5: 2015-2020 (1995) 16
- Bioorg Med Chem Lett 6: 1759-1764 (1996) 14
- Bioorg Med Chem Lett 5: 2211-6 (1995) 9
- J Med Chem 40: 226-35 (1997) 9
- Bioorg Med Chem Lett 5: 2151-4 (1995) 8
- J Med Chem 39: 5215-27 (1996) 8
- Bioorg Med Chem Lett 5: 2155-2160 (1995) 8
- J Med Chem 53: 1867-70 (2010) 7
- J Med Chem 59: 9277-9294 (2016) 6
- Bioorg Med Chem Lett 5: 2133-8 (1995) 5
- J Med Chem 45: 2624-43 (2002) 3
- J Med Chem 65: 3134-3150 (2022) 2
- Chem Biol 2: 601-8 (1995) 2
- J Med Chem 44: 1530-9 (2001) 1
Institutions 9▿
- TBA 54
- Sphinx Laboratories 28
- Eli Lilly 9
- University Of Michigan 7
- Universit£ 6
- Sphinx Pharmaceuticals 5
- University of California San Diego 2
- Mcgill University 2
- University of California At San Diego 1
Affinity: 0.074 to 7.4E+3 nM▿
- Ki 2
- IC50 108
- Kd 4
- Affinity ≤ nM
Xtal structures: 0
Docked structures: 1
Catalog Cmpds: 1