BDBM296744 US10112942, Example 479::US10137124, Example 479::US10172851, Example 479::US10555944, Example 479::US10953005, Example 479

SMILES COc1ncc(CN2C3CC2CN(C3)c2ccc(cn2)-c2cc(OC[C@H](C)O)cn3ncc(C#N)c23)cc1Cl

InChI Key InChIKey=QTGZMXGBBPZWRQ-YTXWROIDSA-N

Data  15 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 296744   

TargetProto-oncogene tyrosine-protein kinase receptor Ret(Homo sapiens (Human))
Array Biopharma

US Patent
LigandPNGBDBM296744(US10112942, Example 479 | US10137124, Example 479 ...)
Affinity DataIC50:  12.6nMpH: 7.4Assay Description:Compounds of Formula I were screened for their ability to inhibit wildtype and V804M mutant RET kinase using CisBio's HTRF® KinEASE¿-TK assay tec...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProto-oncogene tyrosine-protein kinase receptor Ret [G810R](Homo sapiens (Human))
Array Biopharma

US Patent
LigandPNGBDBM296744(US10112942, Example 479 | US10137124, Example 479 ...)
Affinity DataIC50:  242nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProto-oncogene tyrosine-protein kinase receptor Ret [V804M](Homo sapiens (Human))
Array Biopharma

US Patent
LigandPNGBDBM296744(US10112942, Example 479 | US10137124, Example 479 ...)
Affinity DataIC50:  51.4nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent