BDBM50544628 CHEMBL4638006

SMILES COc1cccc(C(=O)C2CCN(CCc3ccc(F)cc3)CC2)c1OC

InChI Key InChIKey=ALTAMTJSSZBUFX-UHFFFAOYSA-N

Data  6 KI  8 IC50  6 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 50544628   

Target5-hydroxytryptamine receptor 2A/Metabotropic glutamate receptor 2(Homo sapiens (Human))
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50544628(CHEMBL4638006)
Affinity DataKi:  3nMAssay Description:Displacement of [3H]-ketanserin from human 5HT2A/mGlu2 receptor expressed in HEK293 cell membranes incubated for 2 hrs by scintillation counting meth...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2A/Metabotropic glutamate receptor 2(Homo sapiens (Human))
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50544628(CHEMBL4638006)
Affinity DataKi:  3nMAssay Description:Displacement of [3H]-ketanserin from human 5HT2A/mGlu2 receptor expressed in HEK293 cell membranes incubated for 2 hrs by scintillation counting meth...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2A/Metabotropic glutamate receptor 2(Homo sapiens (Human))
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50544628(CHEMBL4638006)
Affinity DataKi:  8.70nMAssay Description:Displacement of [3H]-ketanserin from human 5HT2A/mGlu2 receptor expressed in HEK293 cell co-expressing Gqo5 membranes incubated for 2 hrs by scintill...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2A/Metabotropic glutamate receptor 2(Homo sapiens (Human))
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50544628(CHEMBL4638006)
Affinity DataKi:  8.70nMAssay Description:Displacement of [3H]-ketanserin from human 5HT2A/mGlu2 receptor expressed in HEK293 cell co-expressing Gqo5 membranes incubated for 2 hrs by scintill...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2A/Metabotropic glutamate receptor 2(Homo sapiens (Human))
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50544628(CHEMBL4638006)
Affinity DataEC50: >5.00E+4nMAssay Description:Agonist activity at human 5HT2A/mGlu2 receptor expressed in HEK293 cells co-expressing Gqo5 assessed as increase in intracellular Ca2+ mobilization i...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2A/Metabotropic glutamate receptor 2(Homo sapiens (Human))
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50544628(CHEMBL4638006)
Affinity DataIC50:  6.20nMAssay Description:Antagonist activity at human 5HT2A/mGlu2 receptor expressed in HEK293 cells assessed as inhibition of 5HT-induced intracellular Ca2+ mobilization inc...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2A/Metabotropic glutamate receptor 2(Homo sapiens (Human))
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50544628(CHEMBL4638006)
Affinity DataIC50:  6.20nMAssay Description:Antagonist activity at human 5HT2A/mGlu2 receptor expressed in HEK293 cells assessed as inhibition of 5HT-induced intracellular Ca2+ mobilization inc...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2A/Metabotropic glutamate receptor 2(Homo sapiens (Human))
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50544628(CHEMBL4638006)
Affinity DataIC50:  5.5nMAssay Description:Antagonist activity at human 5HT2A/mGlu2 receptor expressed in HEK293 cells co-expressing Gqo5 assessed as inhibition of 5HT-induced intracellular Ca...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2A/Metabotropic glutamate receptor 2(Homo sapiens (Human))
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50544628(CHEMBL4638006)
Affinity DataIC50:  5.40nMAssay Description:Antagonist activity at human 5HT2A/mGlu2 receptor expressed in HEK293 cells co-expressing Gqo5 assessed as inhibition of 5HT-induced intracellular Ca...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2A/Metabotropic glutamate receptor 2(Homo sapiens (Human))
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50544628(CHEMBL4638006)
Affinity DataEC50: <5.01E+4nMAssay Description:Agonist activity at human 5HT2A/mGlu2 receptor expressed in HEK293 cells co-expressing Gqo5 assessed as increase in intracellular Ca2+ mobilization i...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2A/Metabotropic glutamate receptor 2(Homo sapiens (Human))
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50544628(CHEMBL4638006)
Affinity DataIC50:  24nMAssay Description:Antagonist activity at human 5HT2A/mGlu2 receptor expressed in HEK293 cells co-expressing Gqo5 assessed as inhibition of glutamate-induced intracellu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2A/Metabotropic glutamate receptor 2(Homo sapiens (Human))
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50544628(CHEMBL4638006)
Affinity DataIC50:  24nMAssay Description:Antagonist activity at human 5HT2A/mGlu2 receptor expressed in HEK293 cells co-expressing Gqo5 assessed as inhibition of glutamate-induced intracellu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed