BDBM379774 US9926281, Compound 279::US9926281, Compound 448

SMILES COCC1(CC(C)C(=O)N2CCN(CC2)c2cc(F)c(Cl)c(F)c2)NC(=O)NC1=O

InChI Key InChIKey=UHKJKGYIHRIXMQ-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 379774   

TargetA disintegrin and metalloproteinase with thrombospondin motifs 5(Homo sapiens (Human))
Galapagos

US Patent
LigandPNGBDBM379774(US9926281, Compound 279 | US9926281, Compound 448)
Affinity DataIC50:  19nMAssay Description:ADAMTS-5:Protocol 2: The basis for the assay is the cleavage of the substrate TBIS-1 (5 FAM-TEGEARGSVILLK (5TAMRA)K-NH2) (SEQ ID No 2) by human ADAMT...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetA disintegrin and metalloproteinase with thrombospondin motifs 5(Homo sapiens (Human))
Galapagos

US Patent
LigandPNGBDBM379774(US9926281, Compound 279 | US9926281, Compound 448)
Affinity DataIC50:  19nMAssay Description:ADAMTS-5:Protocol 2: The basis for the assay is the cleavage of the substrate TBIS-1 (5 FAM-TEGEARGSVILLK (5TAMRA)K-NH2) (SEQ ID No 2) by human ADAMT...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent