BDBM50079652 (E)-1-[(R)-2-(2-Hydroxy-ethyl)-piperidin-1-yl]-3-(2-phenyl-pyrazolo[1,5-a]pyridin-3-yl)-propenone::(R)-1-(2-(2-hydroxyethyl)piperidin-1-yl)-3-(2-phenylpyrazolo[1,5-a]pyridin-3-yl)prop-2-en-1-one::1-[2-(2-Hydroxy-ethyl)-piperidin-1-yl]-3-(2-phenyl-pyrazolo[1,5-a]pyridin-3-yl)-propenone::CHEMBL440115::FK-453

SMILES OCC[C@H]1CCCCN1C(=O)\C=C\c1c(nn2ccccc12)-c1ccccc1

InChI Key InChIKey=OPLOPFHUHFGKMJ-JXOMPUQVSA-N

Data  8 KI  12 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 50079652   

TargetAdenosine receptor A1(Homo sapiens (Human))
Fujisawa Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50079652((E)-1-[(R)-2-(2-Hydroxy-ethyl)-piperidin-1-yl]-3-(...)
Affinity DataKi:  0.490nMAssay Description:Adenosine A1 receptor binding using [3H]DPCPX in human cortical membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(Rattus norvegicus (rat))
Fujisawa Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50079652((E)-1-[(R)-2-(2-Hydroxy-ethyl)-piperidin-1-yl]-3-(...)
Affinity DataKi:  0.490nMAssay Description:Adenosine A1 receptor binding using [3H]DPCOX in rat cortical membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(Homo sapiens (Human))
Fujisawa Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50079652((E)-1-[(R)-2-(2-Hydroxy-ethyl)-piperidin-1-yl]-3-(...)
Affinity DataKi:  0.490nMAssay Description:Displacement of [3H]CCPA from human adenosine A1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(Mus musculus)
University Of Bonn

Curated by ChEMBL
LigandPNGBDBM50079652((E)-1-[(R)-2-(2-Hydroxy-ethyl)-piperidin-1-yl]-3-(...)
Affinity DataKi:  0.550nMAssay Description:Binding affinity to mouse adenosine A1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(Homo sapiens (Human))
Fujisawa Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50079652((E)-1-[(R)-2-(2-Hydroxy-ethyl)-piperidin-1-yl]-3-(...)
Affinity DataKi:  18nMAssay Description:Binding Affinity towards Adenosine A1 receptor expressed in CHO-K1 cells versus [3H]-CCPAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(Rattus norvegicus (rat))
Fujisawa Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50079652((E)-1-[(R)-2-(2-Hydroxy-ethyl)-piperidin-1-yl]-3-(...)
Affinity DataIC50:  17nMAssay Description:Displacement of [3H]DPCPX from adenosine A1 receptor in rat brain cortical membrane in presence of 100 uM GTPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(Rattus norvegicus (rat))
Fujisawa Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50079652((E)-1-[(R)-2-(2-Hydroxy-ethyl)-piperidin-1-yl]-3-(...)
Affinity DataIC50:  1.01E+4nMAssay Description:Inhibition of [3H]-CHA binding against Adenosine A1 receptors of rat cortical membranesMore data for this Ligand-Target Pair
In DepthDetails Article
TargetAdenosine receptor A1(Rattus norvegicus (rat))
Fujisawa Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50079652((E)-1-[(R)-2-(2-Hydroxy-ethyl)-piperidin-1-yl]-3-(...)
Affinity DataIC50:  17.2nMAssay Description:Inhibitory activity against cyclic AMP production in rat Adenosine A1 receptor assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(Rattus norvegicus (rat))
Fujisawa Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50079652((E)-1-[(R)-2-(2-Hydroxy-ethyl)-piperidin-1-yl]-3-(...)
Affinity DataIC50:  17nMAssay Description:Inhibitory activity against Adenosine A1 Receptor using [3H]-CHA in rat cortical membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(GUINEA PIG)
TBA

Curated by ChEMBL
LigandPNGBDBM50079652((E)-1-[(R)-2-(2-Hydroxy-ethyl)-piperidin-1-yl]-3-(...)
Affinity DataIC50:  1.18E+3nMAssay Description:Inhibition of adenosine induced negative inotropic activity against guinea-pig atria (Adenosine A1 receptor)More data for this Ligand-Target Pair
In DepthDetails Article