BDBM50428341 CHEMBL2331713

SMILES NC1=N[C@]2(C[C@H]2CCS1)c1cc(NC(=O)c2ccc(cn2)C#N)ccc1F

InChI Key InChIKey=WTFJZOZDEFATIG-BLVKFPJESA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50428341   

TargetBeta-secretase 2(Rat)
Janssen Pharmaceutica

Curated by ChEMBL
LigandPNGBDBM50428341(CHEMBL2331713)
Affinity DataIC50:  5nMAssay Description:Inhibition of BACE2 in rat INS-1E cells assessed as TMEM27 cleavage preincubated for 2 hrs followed by doxycycline addition measured after 46 hrs by ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 2(Rat)
Janssen Pharmaceutica

Curated by ChEMBL
LigandPNGBDBM50428341(CHEMBL2331713)
Affinity DataIC50:  1nMAssay Description:Inhibition of BACE2-mediated TMEM27 cleavage in rat INS-1E cells expressing doxycycline-dependent human full-length TMEM27 by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 2(Rat)
Janssen Pharmaceutica

Curated by ChEMBL
LigandPNGBDBM50428341(CHEMBL2331713)
Affinity DataIC50:  5nMAssay Description:Inhibition of BACE2-mediated TMEM27 cleavage in rat INS-1E cells expressing doxycycline-dependent human full-length TMEM27 by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed