BDBM451774 US10710980, Example 6::US10947218, Example 6

SMILES Nc1ncc(cc1C(=O)N[C@H]1CC[C@H](O)CC1)-c1ccc(cc1)[C@@]12C[C@@H]1CN(C2)C(CF)CF

InChI Key InChIKey=ZNGBDCDUILRYET-QGKKGPLKSA-N

Data  14 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 451774   

TargetBone morphogenetic protein receptor type-1A [198-525](Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM451774(US10710980, Example 6 | US10947218, Example 6)
Affinity DataIC50:  940nMAssay Description:The assays were performed in 384-well, low volume microtiter assay plates in a final reaction volume of 6 ul. Dose-response curves were generated by ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBone morphogenetic protein receptor type-1A [198-525](Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM451774(US10710980, Example 6 | US10947218, Example 6)
Affinity DataIC50:  940nMAssay Description:A kinase selectivity panel which measures autophosphorylation using the ADP-Glo Kinase Assay (Promega, V9101) was set-up for wild-type ALK2 (aa172-49...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent