BDBM10880 AZA::AZA2::AZM acetazolamide::Acerazolamide, AAZ::Acetazolamide::Acetazolamide (AAZ)::Acetazolamide (AZA)::Acetazolamide (AZM)::Acetazolamide, 5::Acetazolamide, AAZ::Acetazolamide, AZA::Acetazolamide, AZM::CHEMBL20::N-(5-sulfamoyl-1,3,4-thiadiazol-2-yl)acetamide::Sulfonamide, 1::US10172837, Acetazolamide::US11278534, Example acetazolamide::US11535599, Example acetazolamide::sulfonamide 1
SMILES CC(=O)Nc1nnc(s1)S(N)(=O)=O
InChI Key InChIKey=BZKPWHYZMXOIDC-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 520 hits for monomerid = 10880
Affinity DataKi: 0.25nMAssay Description:Inhibition of human carbonic anhydrase-1 preincubated for 15 mins by stopped flow CO2 dehydration methodMore data for this Ligand-Target Pair
3D Structure (crystal)Affinity DataKi: 0.747nM ΔG°: -12.4kcal/mole IC50: 0.996nMpH: 7.4 T: 25°CAssay Description:Esterase activity assay was performed based on the method of by Verpoorte et al. [Verpoorte et al., J. Biol. Chem., 242:4221-4229] as described in pr...More data for this Ligand-Target Pair
Affinity DataKi: 0.747nMAssay Description:Binding affinity to human CA1 assessed as inhibition constant using 4-nitrophenylacetate as substrate by spectrophotometrical analysisMore data for this Ligand-Target Pair
Affinity DataKi: 4.40nMAssay Description:Inhibition of human CAH1 expressed in Escherichia coli BL21 (DE3) by stopped flow CO2 hydration assayMore data for this Ligand-Target Pair
Affinity DataKi: 8.90nMAssay Description:Inhibition of carbonic anhydrase-1 in human erythrocyte membranes assessed as reduction in H+ release using CO2 as substrate by bromine thymol blue i...More data for this Ligand-Target Pair
Affinity DataKi: 12nMAssay Description:Inhibition of human carbonic anhydrase 1-catalyzed CO2 hydration preincubated for 10 mins by stopped-flow assayMore data for this Ligand-Target Pair
Affinity DataKi: 12nMAssay Description:Inhibition of human cytomegalovirus DNA polymerase (95 uL) activity in a solution containing 6.4 mM HEPES (pH 7.5), incubation for 12 minutes at 26 d...More data for this Ligand-Target Pair
Affinity DataKi: 26nMAssay Description:Binding affinity to human recombinant CA1 assessed as inhibition constant incubated for 15 mins prior to testing by phenol red based stopped-flow CO2...More data for this Ligand-Target Pair
Affinity DataKi: 51nMAssay Description:Binding affinity to human CA1 assessed as inhibition constant by esterase activity assayMore data for this Ligand-Target Pair
Affinity DataKi: 53.0nM IC50: 141nMAssay Description:CA isoenzymes activities were determined in according to the method of Verpoorte et al. (76) described previously (77). The increasing in absorbance ...More data for this Ligand-Target Pair
Affinity DataKi: 61nMAssay Description:Inhibition of acetylcholinesterase (unknown origin) assessed as AChI hydrolysis using AChI and DTNB as substrate by Ellman's methodMore data for this Ligand-Target Pair
Affinity DataKi: 165nMAssay Description:Binding affinity to human CA1 assessed as inhibition constant by SDS-PAGE analysisMore data for this Ligand-Target Pair
Affinity DataKi: 165nMAssay Description:Inhibition of human CA1 by UV spectrophotometric analysisMore data for this Ligand-Target Pair
Affinity DataKi: 182nMAssay Description:Inhibition of human CA1More data for this Ligand-Target Pair
Affinity DataKi: 182nMAssay Description:Inhibition of human CA1 by stopped-flow assayMore data for this Ligand-Target Pair
Affinity DataKi: 184nMAssay Description:Inhibition of human CA1 using para-nitrophenylacetate as substrate measured over 3 mins by UV-vis spectrophotometric methodMore data for this Ligand-Target Pair
Affinity DataKi: 184nMAssay Description:Inhibition of human CA-1 using p-nitro-phenylacetate as substrate by Lineweaver-Burk plot analysisMore data for this Ligand-Target Pair
Affinity DataKi: 200nMAssay Description:Inhibition of human carbonic anhydrase 1 by Stopped-Flow CO2 Hydrase assayMore data for this Ligand-Target Pair
Affinity DataKi: 200nMAssay Description:Inhibitory activity against human carbonic anhydrase I (hCA I)More data for this Ligand-Target Pair
Affinity DataKi: 204nMAssay Description:Inhibition of human carbonic anhydrase 1 using 4-nitrophenylacetate as substrate by Lineweaver-Burk plot analysisMore data for this Ligand-Target Pair
Affinity DataKi: 250nMAssay Description:Inhibition of human carbonic anhydrase 1 assessed as inhibition constantMore data for this Ligand-Target Pair
Affinity DataKi: 250nMAssay Description:Inhibition of human recombinant carbonic anhydrase 1 assessed as inhibition constant preincubated for 15 mins by phenol red dye based stopped flow CO...More data for this Ligand-Target Pair
Affinity DataKi: 250nMAssay Description:Binding affinity to human CA1 assessed as inhibition constantMore data for this Ligand-Target Pair
Affinity DataKi: 250nMAssay Description:Inhibition of human carbonic anhydrase 1 by stopped-flow CO2 hydration assayMore data for this Ligand-Target Pair
Affinity DataKi: 250nMAssay Description:Inhibition of human CA1 incubated for 15 mins prior to testing by phenol red dye based stopped flow CO2 hydration assayMore data for this Ligand-Target Pair
Affinity DataKi: 250nMAssay Description:Inhibition of human CA1 preincubated for 15 mins by phenol red dye based stopped flow CO2 hydration assayMore data for this Ligand-Target Pair
Affinity DataKi: 250nMAssay Description:Inhibition of human CA1 preincubated for 15 mins by phenol red dye based stopped flow CO2 hydration assayMore data for this Ligand-Target Pair
Affinity DataKi: 250nMAssay Description:Inhibition of human CA1 preincubated for 15 mins by phenol red dye based stopped flow CO2 hydration assayMore data for this Ligand-Target Pair
Affinity DataKi: 250nMAssay Description:Inhibition of human CA1 preincubated for 15 mins by phenol red dye based stopped flow CO2 hydration assayMore data for this Ligand-Target Pair
Affinity DataKi: 250nMAssay Description:Inhibition of human recombinant CA1 assessed as inhibition constant pre-incubated for 15 mins measured by phenol red dye based stopped flow CO2 hydra...More data for this Ligand-Target Pair
Affinity DataKi: 250nMAssay Description:Inhibition of human carbonic anhydrase 1 assessed as inhibition constant incubated for 15 mins prior to testing by phenol red based stopped-flow CO2 ...More data for this Ligand-Target Pair
Affinity DataKi: 250nMAssay Description:Inhibition of human carbonic anhydrase 1 by stopped flow CO2 assayMore data for this Ligand-Target Pair
Affinity DataKi: 250nMAssay Description:Inhibition of recombinant human carbonic anhydrase 1 incubated for 15 mins by phenol red based stopped-flow CO2 hydration assayMore data for this Ligand-Target Pair
Affinity DataKi: 250nMAssay Description:Inhibition of human recombinant carbonic anhydrase 1 assessed as inhibition constant incubated for 10 mins by phenol red dye based stopped-flow CO2 h...More data for this Ligand-Target Pair
Affinity DataKi: 250nMAssay Description:Inhibition of recombinant human CA1 pre-incubated for 15 mins by phenol red dye based stopped flow CO2 hydration assayMore data for this Ligand-Target Pair
Affinity DataKi: 250nMAssay Description:Binding affinity to human CA1 assessed as inhibition constant by stopped-flow CO2 hydration assayMore data for this Ligand-Target Pair
Affinity DataKi: 250nMAssay Description:Inhibition of recombinant human carbonic anhydrase 1 assessed as inhibition constant preincubated for 15 mins by measured for 10 to 100 secs by pheno...More data for this Ligand-Target Pair
Affinity DataKi: 250nMAssay Description:Binding affinity to human recombinant CA1 assessed as inhibition constant incubated for 10 mins prior to testing by phenol red based stopped-flow CO2...More data for this Ligand-Target Pair
Affinity DataKi: 250nMAssay Description:Inhibition of recombinant human CA 1 preincubated for 15 mins by phenol red dye based stopped flow CO2 hydration assayMore data for this Ligand-Target Pair
Affinity DataKi: 250nMAssay Description:Inhibition of recombinant human carbonic anhydrase 1 preincubated for 10 mins and measured by phenol red based stopped-flow CO2 hydration assayMore data for this Ligand-Target Pair
Affinity DataKi: 250nMAssay Description:Inhibition of human CA1More data for this Ligand-Target Pair
Affinity DataKi: 250nMAssay Description:Inhibition of human CA1More data for this Ligand-Target Pair
Affinity DataKi: 250nMAssay Description:Inhibition of recombinant human CA1 pre-incubated for 15 mins measured by phenol red dye based stopped flow CO2 hydration assayMore data for this Ligand-Target Pair
Affinity DataKi: 250nMAssay Description:Inhibition of recombinant human carbonic anhydrase 1 pre-incubated for 10 mins by stopped flow CO2 hydrase assayMore data for this Ligand-Target Pair
Affinity DataKi: 250nMAssay Description:Inhibition of human CA1 by stopped-flow carbon dioxide hydration assayMore data for this Ligand-Target Pair
Affinity DataKi: 250nMAssay Description:Inhibition of human CA1 incubated for 15 mins by stopped-flow CO2 hydration kinetic assay based Cheng-Prusoff equation analysisMore data for this Ligand-Target Pair
Affinity DataKi: 250nMAssay Description:Inhibition of recombinant human carbonic anhydrase 1 measured for 10 to 100 secs by phenol red-based stopped-flow CO2 hydration assayMore data for this Ligand-Target Pair
Affinity DataKi: 250nMAssay Description:Inhibition of recombinant human carbonic anhydrase 1 preincubated with enzyme for 15 mins by phenol red dye based stopped flow CO2 hydrase assayMore data for this Ligand-Target Pair
Affinity DataKi: 250nMAssay Description:Inhibition of recombinant human carbonic anhydrase 1 by stopped flow CO2 hydrase assayMore data for this Ligand-Target Pair
Affinity DataKi: 250nMAssay Description:Inhibition of recombinant human CA1 expressed in Escherichia coli BL21 preincubated for 15 mins by phenol red dye-based stopped-flow CO2 hydration as...More data for this Ligand-Target Pair