BDBM50237710 4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl]-3-[(4-pyridin-3-ylpyrimidin-2-yl)amino]benzamide::AMN 107::AMN107::CHEMBL255863::NILOTINIB::US11649218, Example Nilotinib
SMILES Cc1cn(cn1)-c1cc(NC(=O)c2ccc(C)c(Nc3nccc(n3)-c3cccnc3)c2)cc(c1)C(F)(F)F
InChI Key InChIKey=HHZIURLSWUIHRB-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 9 hits for monomerid = 50237710
TargetDiscoidin domain-containing receptor 2(Homo sapiens (Human))
Massachusetts General Hospital and Harvard Medical School
Massachusetts General Hospital and Harvard Medical School
Affinity DataIC50: 0.5nMAssay Description:Tet inducible human DDR1 over-expressing U2OS was pre-treated by media containing each of the compound for 1 hour and treated by changing the media t...More data for this Ligand-Target Pair
TargetDiscoidin domain-containing receptor 2(Homo sapiens (Human))
Massachusetts General Hospital and Harvard Medical School
Massachusetts General Hospital and Harvard Medical School
Affinity DataIC50: 2nMAssay Description:Inhibition of wild type DDR2 (unknown origin) preincubated for 30 mins before substrate addition by FRET assayMore data for this Ligand-Target Pair
TargetDiscoidin domain-containing receptor 2(Homo sapiens (Human))
Massachusetts General Hospital and Harvard Medical School
Massachusetts General Hospital and Harvard Medical School
Affinity DataKd: 6nMAssay Description:Binding affinity to wild type DDR2 (unknown origin) by FLiK assayMore data for this Ligand-Target Pair
TargetDiscoidin domain-containing receptor 2(Homo sapiens (Human))
Massachusetts General Hospital and Harvard Medical School
Massachusetts General Hospital and Harvard Medical School
Affinity DataKd: 75nMAssay Description:Binding affinity to human acrylodan-labeled N-terminal His-tagged DDR2 (558 to 855 aa) by FLiK assayMore data for this Ligand-Target Pair
TargetDiscoidin domain-containing receptor 2(Homo sapiens (Human))
Massachusetts General Hospital and Harvard Medical School
Massachusetts General Hospital and Harvard Medical School
Affinity DataIC50: 55nMAssay Description:Inhibition of DDR2 (unknown origin) assessed as reduction in collagen-induced DDR2 activationMore data for this Ligand-Target Pair
TargetDiscoidin domain-containing receptor 2(Homo sapiens (Human))
Massachusetts General Hospital and Harvard Medical School
Massachusetts General Hospital and Harvard Medical School
Affinity DataIC50: 5.20nMAssay Description:Inhibition of autophosphorylation of DDR2 expressed in HEK293 cells by ELISAMore data for this Ligand-Target Pair
TargetDiscoidin domain-containing receptor 2(Homo sapiens (Human))
Massachusetts General Hospital and Harvard Medical School
Massachusetts General Hospital and Harvard Medical School
Affinity DataKd: 33nMAssay Description:Binding constant for DDR2 kinase domainMore data for this Ligand-Target Pair
TargetDiscoidin domain-containing receptor 2(Homo sapiens (Human))
Massachusetts General Hospital and Harvard Medical School
Massachusetts General Hospital and Harvard Medical School
Affinity DataKd: 6.20nMAssay Description:Binding affinity to human DDR2More data for this Ligand-Target Pair
TargetDiscoidin domain-containing receptor 2(Homo sapiens (Human))
Massachusetts General Hospital and Harvard Medical School
Massachusetts General Hospital and Harvard Medical School
Affinity DataIC50: 105nMAssay Description:Inhibition of DDR2 (unknown origin) using fluorescein-labeled poly GAT as substrate incubated for 1 hr prior to substrate addition measured after 1 h...More data for this Ligand-Target Pair