BDBM50026622 CHEMBL408982

SMILES CCN1\C(Sc2ccc(OC)cc12)=C\C(C)=O

InChI Key InChIKey=BGVLELSCIHASRV-QPEQYQDCSA-N

Data  14 IC50  6 Kd

PDB links: 7 PDB IDs match this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50026622   

TargetDual specificity tyrosine-phosphorylation-regulated kinase 1A(Homo sapiens (Human))
Saarland University

Curated by ChEMBL
LigandPNGBDBM50026622(CHEMBL408982)
Affinity DataIC50:  830nMAssay Description:Inhibition of recombinant Dyrk1A (unknown origin) using KKISGRLSPIMTEQ-NH2 peptide substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity tyrosine-phosphorylation-regulated kinase 1A(Homo sapiens (Human))
Saarland University

Curated by ChEMBL
LigandPNGBDBM50026622(CHEMBL408982)
Affinity DataIC50:  930nMAssay Description:Inhibition of Dyrk1A (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity tyrosine-phosphorylation-regulated kinase 1A(Homo sapiens (Human))
Saarland University

Curated by ChEMBL
LigandPNGBDBM50026622(CHEMBL408982)
Affinity DataIC50:  71nMAssay Description:Inhibition of recombinant human DYRK1A expressed in insect cells using RRRFRPASPLRGPPK peptide as substrate after 40 mins in presence of [gamma-33P]-...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity tyrosine-phosphorylation-regulated kinase 1A(Homo sapiens (Human))
Saarland University

Curated by ChEMBL
LigandPNGBDBM50026622(CHEMBL408982)
Affinity DataIC50:  930nMAssay Description:Inhibition of human recombinant full length GST-tagged DYRK1A expressed in baculovirus expression system after 10 mins in presence of [gamma33P-ATP] ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity tyrosine-phosphorylation-regulated kinase 1A(Mus musculus)
German University In Cairo

Curated by ChEMBL
LigandPNGBDBM50026622(CHEMBL408982)
Affinity DataIC50:  12nMAssay Description:Inhibition of mouse glutathione S-transferase-tagged Dyrk1A expressed in Escherichia coli DH5alpha using NH2-RSPSYGRSRSRSRSRSRSRSRSNSRSRSY-OH peptide...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetDual specificity tyrosine-phosphorylation-regulated kinase 1A(Homo sapiens (Human))
Saarland University

Curated by ChEMBL
LigandPNGBDBM50026622(CHEMBL408982)
Affinity DataKd:  12nMAssay Description:Binding affinity to DYRK1A (unknown origin) assessed as dissociation constantMore data for this Ligand-Target Pair
In DepthDetails PubMed