BDBM21898 8-chloro-4-[(3-chloro-4-fluorophenyl)amino]-6-[(1H-imidazol-4-ylmethyl)amino]quinoline-3-carbonitrile::CHEMBL436817::Cyanoquinoline, 11

SMILES Fc1ccc(Nc2c(cnc3c(Cl)cc(NCc4cnc[nH]4)cc23)C#N)cc1Cl

InChI Key InChIKey=ONXROKMQGCSOMG-UHFFFAOYSA-N

Data  13 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 21898   

TargetEpidermal growth factor receptor(Homo sapiens (Human))
Wyeth Research

LigandPNGBDBM21898(8-chloro-4-[(3-chloro-4-fluorophenyl)amino]-6-[(1H...)
Affinity DataIC50:  1.80E+3nMAssay Description:EGFR kinase activity was assayed using poly(Glu4-Tyr) as a substrate. The phosphorylation of tyrosine residue was detected by an ELISA. IC50 calculat...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Wyeth Research

LigandPNGBDBM21898(8-chloro-4-[(3-chloro-4-fluorophenyl)amino]-6-[(1H...)
Affinity DataIC50: >4.00E+4nMAssay Description:Inhibition of human EGFR by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed