BDBM50237710 4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl]-3-[(4-pyridin-3-ylpyrimidin-2-yl)amino]benzamide::AMN 107::AMN107::CHEMBL255863::NILOTINIB::US11649218, Example Nilotinib
SMILES Cc1cn(cn1)-c1cc(NC(=O)c2ccc(C)c(Nc3nccc(n3)-c3cccnc3)c2)cc(c1)C(F)(F)F
InChI Key InChIKey=HHZIURLSWUIHRB-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 6 hits for monomerid = 50237710
TargetEpithelial discoidin domain-containing receptor 1(Homo sapiens (Human))
Massachusetts General Hospital and Harvard Medical School
Massachusetts General Hospital and Harvard Medical School
Affinity DataIC50: 43nMAssay Description:Tet inducible human DDR1 over-expressing U2OS was pre-treated by media containing each of the compound for 1 hour and treated by changing the media t...More data for this Ligand-Target Pair
TargetEpithelial discoidin domain-containing receptor 1(Homo sapiens (Human))
Massachusetts General Hospital and Harvard Medical School
Massachusetts General Hospital and Harvard Medical School
Affinity DataIC50: 43nMAssay Description:Inhibition of DDR1b (unknown origin) assessed as reduction in collagen-induced DDR1b activationMore data for this Ligand-Target Pair
TargetEpithelial discoidin domain-containing receptor 1(Homo sapiens (Human))
Massachusetts General Hospital and Harvard Medical School
Massachusetts General Hospital and Harvard Medical School
Affinity DataIC50: 3.70nMAssay Description:Inhibition of autophosphorylation of DDR1 expressed in HEK293 cells by ELISAMore data for this Ligand-Target Pair
TargetEpithelial discoidin domain-containing receptor 1(Homo sapiens (Human))
Massachusetts General Hospital and Harvard Medical School
Massachusetts General Hospital and Harvard Medical School
Affinity DataKd: 1.10nMAssay Description:Binding constant for DDR1 kinase domainMore data for this Ligand-Target Pair
TargetEpithelial discoidin domain-containing receptor 1(Homo sapiens (Human))
Massachusetts General Hospital and Harvard Medical School
Massachusetts General Hospital and Harvard Medical School
Affinity DataIC50: 33nMAssay Description:Inhibition of DDR1 (unknown origin) using fluorescein-labeled poly GAT as substrate incubated for 1 hr prior to substrate addition measured after 1 h...More data for this Ligand-Target Pair
TargetEpithelial discoidin domain-containing receptor 1(Homo sapiens (Human))
Massachusetts General Hospital and Harvard Medical School
Massachusetts General Hospital and Harvard Medical School
Affinity DataIC50: <100nMAssay Description:Inhibition of kinobead binding to DDR1 in human K562 cells incubated for 30 mins by iTRAQ reagent-based mass spectrometric methodMore data for this Ligand-Target Pair