BDBM562345 12-Ethyl-8,9,11-trimethyl-1-(3-(naphthalen-1-yloxy)propyl)-5,6,9,11-tetrahydro-4H,8H-pyrazolo[3′,4′:4,5][1]thia[2,8]diazacycloundecino[6,7,8-hi]indole-2-carboxylic acid 7,7-dioxide (Mixture of Stereoisomers)::US11401278, Example 18
SMILES CCc1c-2c(nn1C)C(C)N(C)S(=O)(=O)CCCn1c(C(O)=O)c(CCCOc3cccc4ccccc34)c3cccc-2c13
InChI Key InChIKey=CYAZPSVAIWRWMS-UHFFFAOYSA-N
Data 3 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 1 hit for monomerid = 562345
TargetInduced myeloid leukemia cell differentiation protein Mcl-1 [173-329]/Phorbol-Phorbol-12-myristate-13-acetate-induced protein 1 [26-43](Homo sapiens (Human))
The Broad Institute
US Patent
The Broad Institute
US Patent
Affinity DataIC50: 7.80nMAssay Description:MCL-1/Noxa BH3 Peptide (MCL-1 Assay): From there, 50 nl were transferred in a dark test plate (Greiner Bio-One, Frickenhausen, Germany). The assay wa...More data for this Ligand-Target Pair