BDBM307668 2-(6-(4-cyclopropyl- 4H-1,2,4-triazol-3- yl)pyridin-2-yl)-6- (5- cyclopropylpyrazin- 2-yll)isoindolin-1- one::US10150755, Compound 60

SMILES O=C1N(Cc2ccc(cc12)-c1cnc(cn1)C1CC1)c1cccc(n1)-c1nncn1C1CC1

InChI Key InChIKey=ZHTOMHCMNBVCCV-UHFFFAOYSA-N

Data  2 KI  3 IC50  1 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 307668   

TargetMitogen-activated protein kinase kinase kinase 5(Human)
Seal Rock Therapeutics

US Patent
LigandPNGBDBM307668(2-(6-(4-cyclopropyl- 4H-1,2,4-triazol-3- yl)pyridi...)
Affinity DataKi: <200nMAssay Description:The ASK1 enzymatic assay was run following Promega ASK1 Kinase Enzyme System (Cat #V3881). The kit provides the protocol, enzymes and all reagents ne...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

TargetMitogen-activated protein kinase kinase kinase 5(Human)
Seal Rock Therapeutics

US Patent
LigandPNGBDBM307668(2-(6-(4-cyclopropyl- 4H-1,2,4-triazol-3- yl)pyridi...)
Affinity DataIC50: <200nMAssay Description:The ASK1 enzymatic assay was run following Promega ASK1 Kinase Enzyme System (Cat #V3881). The kit provides the protocol, enzymes and all reagents ne...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent