BDBM92862 US9284315, BEZ-235::mTOR Inhibitor, BEZ235
SMILES Cn1c2cnc3ccc(cc3c2n(-c2ccc(cc2)C(C)(C)C#N)c1=O)-c1cnc2ccccc2c1
InChI Key InChIKey=JOGKUKXHTYWRGZ-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 5 hits for monomerid = 92862
TargetPhosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit beta isoform(Human)
Xi'An Jiaotong University
Curated by ChEMBL
Xi'An Jiaotong University
Curated by ChEMBL
Affinity DataIC50: 478nMAssay Description:Inhibition of p110beta/p85alpha (unknown origin) incubated for 40 mins by luciferase based ATP depletion assayMore data for this Ligand-Target Pair
TargetPhosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit beta isoform(Human)
Xi'An Jiaotong University
Curated by ChEMBL
Xi'An Jiaotong University
Curated by ChEMBL
Affinity DataIC50: 16nMAssay Description:Inhibition of recombinant full length human N-terminal His6-tagged PI3K p110beta/p85alpha expressed in baculovirus infected Sf21 cells using PIP2 as ...More data for this Ligand-Target Pair
TargetPhosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit beta isoform(Human)
Xi'An Jiaotong University
Curated by ChEMBL
Xi'An Jiaotong University
Curated by ChEMBL
Affinity DataIC50: 421nMAssay Description:Inhibition of P110beta/p85alpha (unknown origin) using L-alpha-phosphatidylinositol as substrate after 40 mins by ATP depletion assayMore data for this Ligand-Target Pair
TargetPhosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit beta isoform(Human)
Xi'An Jiaotong University
Curated by ChEMBL
Xi'An Jiaotong University
Curated by ChEMBL
Affinity DataIC50: 36nMAssay Description:Inhibition of N-terminal His6-tagged recombinant full-length PI3Kbeta (unknown origin)/untagged recombinant full length p85alpha expressed in baculov...More data for this Ligand-Target Pair
TargetPhosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit beta isoform(Human)
Xi'An Jiaotong University
Curated by ChEMBL
Xi'An Jiaotong University
Curated by ChEMBL
Affinity DataIC50: 704nMAssay Description:Inhibition of recombinant human full length N-terminal GST-tagged PI3Kbeta (1 to 1070 residues)/PIK3R1 (1 to 724 residues) expressed in baculovirus e...More data for this Ligand-Target Pair