BDBM50007203 CHEMBL3237875

SMILES COc1ccc(C[C@H](NC(=O)[C@H](C)NC(=O)CN2CCOCC2)C(=O)N[C@@H](Cc2ccccc2)C(=O)[C@@]2(C)CO2)cc1

InChI Key InChIKey=WQAVPPWWLLVGFK-VTNASVEKSA-N

Data  56 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50007203   

TargetProteasome subunit beta type-10(Homo sapiens (Human))
Leiden Institute Of Chemistry And Netherlands Proteomics Centre

Curated by ChEMBL
LigandPNGBDBM50007203(CHEMBL3237875)
Affinity DataIC50:  590nMAssay Description:Inhibition of proteasome subunit beta-2i in human Raji cells using BODIPY- epoxomicin by fluorescent densitometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProteasome subunit beta type-10(Homo sapiens (Human))
Leiden Institute Of Chemistry And Netherlands Proteomics Centre

Curated by ChEMBL
LigandPNGBDBM50007203(CHEMBL3237875)
Affinity DataIC50:  590nMAssay Description:Inhibition of proteasome subunit beta-2i in human RPMI8226 cells using BODIPY-epoxomicin by fluorescent densitometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProteasome subunit beta type-10(Homo sapiens (Human))
Leiden Institute Of Chemistry And Netherlands Proteomics Centre

Curated by ChEMBL
LigandPNGBDBM50007203(CHEMBL3237875)
Affinity DataIC50:  911nMAssay Description:Inhibition of MECL1 in human MOLT4 cell lysate after 1 hr by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProteasome subunit beta type-10(Homo sapiens (Human))
Leiden Institute Of Chemistry And Netherlands Proteomics Centre

Curated by ChEMBL
LigandPNGBDBM50007203(CHEMBL3237875)
Affinity DataIC50:  4.85E+3nMAssay Description:Inhibition of human 20S immunoproteasome beta-2 using BocLRR-AMC as substrate incubated for 15 mins measured for 45 mins by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProteasome subunit beta type-10(Homo sapiens (Human))
Leiden Institute Of Chemistry And Netherlands Proteomics Centre

Curated by ChEMBL
LigandPNGBDBM50007203(CHEMBL3237875)
Affinity DataIC50:  902nMAssay Description:Inhibition of MECL1 in human MOLT4 cells by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProteasome subunit beta type-10(Homo sapiens (Human))
Leiden Institute Of Chemistry And Netherlands Proteomics Centre

Curated by ChEMBL
LigandPNGBDBM50007203(CHEMBL3237875)
Affinity DataIC50:  902nMAssay Description:Inhibition of MECL1 in human MOLT4 cells by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProteasome subunit beta type-10(Mus musculus)
Kezar Life Sciences

Curated by ChEMBL
LigandPNGBDBM50007203(CHEMBL3237875)
Affinity DataIC50:  699nMAssay Description:Inhibition of MECL1 in mouse A20 cells by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProteasome subunit beta type-10(Mus musculus)
Kezar Life Sciences

Curated by ChEMBL
LigandPNGBDBM50007203(CHEMBL3237875)
Affinity DataIC50:  699nMAssay Description:Inhibition of MECL1 in mouse A20 cells by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProteasome subunit beta type-10(Homo sapiens (Human))
Leiden Institute Of Chemistry And Netherlands Proteomics Centre

Curated by ChEMBL
LigandPNGBDBM50007203(CHEMBL3237875)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human trypsin-like activity of 20s proteasome beta 2i subunit using SUC-VGR-AMC as flurogenic substrate preincubated for 15 mins follow...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed