BDBM296775 6-ethoxy-4-(6-(1-((4- fluorophenyl) sulfonyl)-1,6- diazaspiro[2.5]octan- 6-yl)pyridin-3- yl)pyrazolo[1,5- a]pyridine-3- carbonitrile::US10112942, Example 510::US10137124, Example 510::US10172851, Example 510::US10555944, Example 510::US10953005, Example 510

SMILES CCOc1cc(-c2ccc(nc2)N2CCC3(CN3S(=O)(=O)c3ccc(F)cc3)CC2)c2c(cnn2c1)C#N

InChI Key InChIKey=BZULAVQKDZUFLN-UHFFFAOYSA-N

Data  15 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 296775   

TargetProto-oncogene tyrosine-protein kinase receptor Ret [658-1114,G810R](Homo sapiens (Human))
Eli Lilly

US Patent
LigandPNGBDBM296775(6-ethoxy-4-(6-(1-((4- fluorophenyl) sulfonyl)-1,6-...)
Affinity DataIC50:  192nMAssay Description:The potency of a compound inhibiting G81 OR mutant RET kinase was determined using CisBio's HTRF Kinease-TK assay technology. The assays containe...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent