BDBM77828 US10245267, Example 275::US10709712, Example 275::US9694016, 275

SMILES Cc1ccc(NC(=O)c2cnnc(c2)C(F)(F)F)cc1-c1cnc(OC2CCOCC2)c(c1)N1CCOCC1

InChI Key InChIKey=BYMCFCWJXIQKBB-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 77828   

LigandPNGBDBM77828(US10245267, Example 275 | US10709712, Example 275 ...)
Affinity DataIC50:  0.200nMAssay Description:C-Raf TR refers to a truncated C-Raf protein, a Δ1-324 deletion mutant.C-Raf FL refers to the full-length C-Raf protein.Full length MEK1 with an...More data for this Ligand-Target Pair
In DepthDetails US Patent

LigandPNGBDBM77828(US10245267, Example 275 | US10709712, Example 275 ...)
Affinity DataIC50:  0.200nMAssay Description:Raf and biotinylated Mek, kinase dead, were combined at 2× final concentrations in assay buffer (50 mM Tris, pH 7.5, 15 mM MgCl2, 0.01% BSA and 1 mM ...More data for this Ligand-Target Pair
In DepthDetails US Patent