BDBM21398 4-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-1-(4-fluoro-phenyl)-butan-1-one;propionate(HCl)::4-[4-(4-chlorophenyl)-4-hydroxypiperidin-1-yl]-1-(4-fluorophenyl)butan-1-one::CHEMBL54::CHEMBL545608::Haloperidol::Haloperidol, 1
SMILES OC1(CCN(CCCC(=O)c2ccc(F)cc2)CC1)c1ccc(Cl)cc1
InChI Key InChIKey=LNEPOXFFQSENCJ-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 184 hits for monomerid = 21398
Affinity DataKi: 0.200nMAssay Description:Affinity for sigma receptor type 1 of guinea pig using [3H]ifenprodil or (+)-[3H]pentazocine radioligandMore data for this Ligand-Target Pair
Affinity DataKi: 0.210nMAssay Description:Displacement of [3H]-(+)-pentazocine from sigma1 in human MDA-MB-468 cell membranesMore data for this Ligand-Target Pair
Affinity DataKi: 0.330nMAssay Description:Tested for [3H]-(+)-pentazocine binding to sigma-1 receptor in guinea pig brain membraneMore data for this Ligand-Target Pair
Affinity DataKi: 0.440nMAssay Description:Inhibition of [3H]-pentazocine binding to Sigma opioid receptor type 1More data for this Ligand-Target Pair
Affinity DataKi: 0.600nMAssay Description:The compound was evaluated for affinity at sigma-1 site by inhibition of [3H](+)-pentazocine (PENT) binding in guinea pig brain.More data for this Ligand-Target Pair
Affinity DataKi: 0.600nMAssay Description:Binding affinity for Sigma opioid receptor type 1 in guinea pig brain homogenate with 0.5 nM [3H]-(+)-PENTMore data for this Ligand-Target Pair
TargetSigma non-opioid intracellular receptor 1(Guinea pig)
University of Missouri-Columbia
Curated by ChEMBL
University of Missouri-Columbia
Curated by ChEMBL
Affinity DataKi: 0.830nMAssay Description:Displacement of [3H]-(+)-pentazocine from Sigma1-receptor in guinea pig brain membraneMore data for this Ligand-Target Pair
TargetSigma non-opioid intracellular receptor 1(Guinea pig)
University of Missouri-Columbia
Curated by ChEMBL
University of Missouri-Columbia
Curated by ChEMBL
Affinity DataKi: 0.830nMAssay Description:Displacement of [3H](+)-PTZ from sigma1 receptor in Hartley guinea pig brainMore data for this Ligand-Target Pair
Affinity DataKi: 0.900nMAssay Description:Displacement of [3H](+)-pentazocine from sigma 1 receptor in rat brain homogenateMore data for this Ligand-Target Pair
TargetSigma non-opioid intracellular receptor 1(Guinea pig)
University of Missouri-Columbia
Curated by ChEMBL
University of Missouri-Columbia
Curated by ChEMBL
Affinity DataKi: 1.10nMAssay Description:Displacement of [3H](+)-pentazocine from human sigma1 receptor by PDSP assayMore data for this Ligand-Target Pair
TargetSigma non-opioid intracellular receptor 1(Guinea pig)
University of Missouri-Columbia
Curated by ChEMBL
University of Missouri-Columbia
Curated by ChEMBL
Affinity DataKi: 1.30nMAssay Description:Displacement of [3H]-(+)-pentazocine from sigma-1 receptor in guinea pig brain membranes incubated for 1 hr by liquid scintillation counting methodMore data for this Ligand-Target Pair
TargetSigma non-opioid intracellular receptor 1(Guinea pig)
University of Missouri-Columbia
Curated by ChEMBL
University of Missouri-Columbia
Curated by ChEMBL
Affinity DataKi: 1.30nMAssay Description:Displacement of [3H]-(+)-pentazocine from guinea pig brain sigma1 receptor after 150 mins by scintillation counting analysisMore data for this Ligand-Target Pair
TargetSigma non-opioid intracellular receptor 1(Guinea pig)
University of Missouri-Columbia
Curated by ChEMBL
University of Missouri-Columbia
Curated by ChEMBL
Affinity DataKi: 1.40nMAssay Description:Displacement of [3H]-(+)-pentazocine from sigma-1 receptor in guinea pig brain membranes incubated for 1 hr in presence of 250 uM phenytoin liquid sc...More data for this Ligand-Target Pair
TargetSigma non-opioid intracellular receptor 1(Guinea pig)
University of Missouri-Columbia
Curated by ChEMBL
University of Missouri-Columbia
Curated by ChEMBL
Affinity DataKi: 1.45nMAssay Description:Displacement of [3H](+)-pentazocine from sigma 1 receptor in guinea pig brain homogenates after 1 hr by liquid scintillation countingMore data for this Ligand-Target Pair
TargetSigma non-opioid intracellular receptor 1(Guinea pig)
University of Missouri-Columbia
Curated by ChEMBL
University of Missouri-Columbia
Curated by ChEMBL
Affinity DataKi: 1.45nMAssay Description:Displacement of [3H](+)-pentazocine from sigma 1-type opioid receptor in guinea pig brain homogenatesMore data for this Ligand-Target Pair
TargetSigma non-opioid intracellular receptor 1(Guinea pig)
University of Missouri-Columbia
Curated by ChEMBL
University of Missouri-Columbia
Curated by ChEMBL
Affinity DataKi: 1.5nMAssay Description:Displacement of [3H]-pentazocine from guinea pig sigma1 receptor by liquid scintillation countingMore data for this Ligand-Target Pair
Affinity DataKi: 1.5nMAssay Description:Binding affinity measured at the sigma receptor by the inhibition of [3H]-3-PPP binding to guinea pig cerebellum using unlabeled 3-PPP for nonspecifi...More data for this Ligand-Target Pair
Affinity DataKi: 1.5nMAssay Description:Binding affinity for sigma-1 receptor measured on guinea pig brain membranes using [3H]-(+)-pentazocine as radioligandMore data for this Ligand-Target Pair
Affinity DataKi: 1.60nMAssay Description:Inhibition of [3H]pentazocine binding to sigma-1 sites in guinea pig brain membranesMore data for this Ligand-Target Pair
Affinity DataKi: 1.60nMAssay Description:Displacement of [3H]-(+)-pentazocine from sigma-1 receptor in human Jurkat cell membranes after 2 hrs by liquid scintillation counting methodMore data for this Ligand-Target Pair
TargetSigma non-opioid intracellular receptor 1(Guinea pig)
University of Missouri-Columbia
Curated by ChEMBL
University of Missouri-Columbia
Curated by ChEMBL
Affinity DataKi: 1.60nMAssay Description:Displacement of [3H]-(+)-pentazocine from sigma1 receptor in guinea pig brain membranes incubated for 150 mins by scintillation counting methodMore data for this Ligand-Target Pair
Affinity DataKi: 1.66nMAssay Description:Displacement of [3H](+)Pentazocine from sigma 1 receptor (unknown origin)More data for this Ligand-Target Pair
Affinity DataKi: 1.70nMAssay Description:Displacement of [3H](+)Pentazocine from sigma 1 receptor (unknown origin)More data for this Ligand-Target Pair
Affinity DataKi: 1.70nMAssay Description:Displacement of [3H](+)-pentazocine from sigma 1 receptor in rat brain membrane after 2.5 hrs by scintillation countingMore data for this Ligand-Target Pair
Affinity DataKi: 1.80nMAssay Description:Inhibition of [3H]- pentazocine binding against alpha-1 from guinea pig brainMore data for this Ligand-Target Pair
TargetSigma non-opioid intracellular receptor 1(Guinea pig)
University of Missouri-Columbia
Curated by ChEMBL
University of Missouri-Columbia
Curated by ChEMBL
Affinity DataKi: 1.90nMAssay Description:Displacement of [3H]-(+)-pentazocine from sigma 1 receptor in guinea pig brain membranes after 2 hrs by scintillation countingMore data for this Ligand-Target Pair
Affinity DataKi: 1.90nMAssay Description:Inhibition of sigma 1 receptorMore data for this Ligand-Target Pair
TargetSigma non-opioid intracellular receptor 1(Guinea pig)
University of Missouri-Columbia
Curated by ChEMBL
University of Missouri-Columbia
Curated by ChEMBL
Affinity DataKi: 1.90nMAssay Description:Displacement of [3H](+)-pentazocine from sigma 1 opioid receptor in guinea pig brain membraneMore data for this Ligand-Target Pair
TargetSigma non-opioid intracellular receptor 1(Guinea pig)
University of Missouri-Columbia
Curated by ChEMBL
University of Missouri-Columbia
Curated by ChEMBL
Affinity DataKi: 1.90nMAssay Description:Displacement of [3H](+)-pentazocine from sigma 1 receptor in guinea pig brain membraneMore data for this Ligand-Target Pair
Affinity DataKi: 2nMAssay Description:Displacement of [3H]-(+)-pentazocine from human sigma1 receptor expressed in HEK293 cell membranes incubated for 120 mins by liquid scintillation cou...More data for this Ligand-Target Pair
Affinity DataKi: 2nMAssay Description:Displacement of [3H]-(+)-pentazocine from human sigma-1 receptor expressed in HEK293 membranes incubated for 120 mins by liquid scintillation countin...More data for this Ligand-Target Pair
Affinity DataKi: 2.10nMAssay Description:Displacement of [3H]-(+)-pentazocine from human sigma1 receptor transfected in HEK293 cells after 120 mins by liquid scintillation counting analysisMore data for this Ligand-Target Pair
Affinity DataKi: 2.10nMAssay Description:Displacement of [3H](+)pentazocine from human sigma 1 receptor transfected in HEK293 cell membranes after 120 mins by scintillation counterMore data for this Ligand-Target Pair
TargetSigma non-opioid intracellular receptor 1(Guinea pig)
University of Missouri-Columbia
Curated by ChEMBL
University of Missouri-Columbia
Curated by ChEMBL
Affinity DataKi: 2.20nMAssay Description:Displacement of [3H]-(+)-pentazocine from sigma1 receptor in guinea pig brain membrane after 150 mins by liquid scintillation counting methodMore data for this Ligand-Target Pair
Affinity DataKi: 2.20nMAssay Description:Ability to displace [3H](+)-pentazocine from Sigma opioid receptor type 1 of guinea pig brainMore data for this Ligand-Target Pair
Affinity DataKi: 2.20nMAssay Description:Inhibitory constant against sigma receptor type 1 using 3 nM [3H]pentazocineMore data for this Ligand-Target Pair
TargetSigma non-opioid intracellular receptor 1(Guinea pig)
University of Missouri-Columbia
Curated by ChEMBL
University of Missouri-Columbia
Curated by ChEMBL
Affinity DataKi: 2.20nMAssay Description:Displacement of [3H](+)-pentazocine from sigma 1 receptor in guinea pig brain membraneMore data for this Ligand-Target Pair
TargetSigma non-opioid intracellular receptor 1(Guinea pig)
University of Missouri-Columbia
Curated by ChEMBL
University of Missouri-Columbia
Curated by ChEMBL
Affinity DataKi: 2.20nMAssay Description:Displacement of [3H](+)-pentazocine from sigma 1 receptor in guinea pig brain membrane by liquid scintillation analyzerMore data for this Ligand-Target Pair
Affinity DataKi: 2.20nMAssay Description:Sigma opioid receptor type 1 affinity in guinea pig brain by employing [3H](+)-pentazocine as radioligand.More data for this Ligand-Target Pair
TargetSigma non-opioid intracellular receptor 1(Guinea pig)
University of Missouri-Columbia
Curated by ChEMBL
University of Missouri-Columbia
Curated by ChEMBL
Affinity DataKi: 2.20nMAssay Description:Displacement of [3H]-(+)-pentazocine from sigma 1 receptor in guinea pig brain membrane after 150 mins by liquid scintillation countingMore data for this Ligand-Target Pair
TargetSigma non-opioid intracellular receptor 1(Guinea pig)
University of Missouri-Columbia
Curated by ChEMBL
University of Missouri-Columbia
Curated by ChEMBL
Affinity DataKi: 2.20nMAssay Description:Displacement of [3H]-(+)-pentazocine from sigma 1 receptor in guinea pig brain membranes after 150 minsMore data for this Ligand-Target Pair
TargetSigma non-opioid intracellular receptor 1(Guinea pig)
University of Missouri-Columbia
Curated by ChEMBL
University of Missouri-Columbia
Curated by ChEMBL
Affinity DataKi: 2.20nMAssay Description:Displacement of [3H](+)-pentazocine from sigma 1 receptor in guinea pig brain membranes after 150 mins by microbeta scintillation counting methodMore data for this Ligand-Target Pair
Affinity DataKi: 2.30nMAssay Description:Displacement of [3H]-pentazocine from sigma-1 receptor in human Jurkat cell membrane incubated for 2 hr by liquid scintillation counting methodMore data for this Ligand-Target Pair
TargetSigma non-opioid intracellular receptor 1(Guinea pig)
University of Missouri-Columbia
Curated by ChEMBL
University of Missouri-Columbia
Curated by ChEMBL
Affinity DataKi: 2.5nMAssay Description:Displacement of [3H]-(+)-pentazocine from sigma 1 receptor guinea pig brain membranes incubated for 150 mins by scintillation counting methodMore data for this Ligand-Target Pair
Affinity DataKi: 2.5nMAssay Description:Displacement of [3H]-Pentazocine from sigma 1 receptor (unknown origin) expressed in HEK293T cell membranesMore data for this Ligand-Target Pair
Affinity DataKi: 2.5nMAssay Description:Displacement of [3H]-Pentazocine from sigma 1 receptor (unknown origin) expressed in HEK293T cell membranesMore data for this Ligand-Target Pair
TargetSigma non-opioid intracellular receptor 1(Guinea pig)
University of Missouri-Columbia
Curated by ChEMBL
University of Missouri-Columbia
Curated by ChEMBL
Affinity DataKi: 2.5nMAssay Description:Displacement of [3H]-(+)-pentazocine from sigma1 receptor in guinea pig brain membranes incubated for 1 hr by liquid scintillation counting methodMore data for this Ligand-Target Pair