BDBM50183656 (R)-1-(2-(dimethylamino)-1-(4-methoxyphenyl)ethyl)silinan-1-ol::CHEMBL427215

SMILES COc1ccc(cc1)[C@H](CN(C)C)[Si]1(O)CCCCC1

InChI Key InChIKey=KIXBFSFRCBHKLN-INIZCTEOSA-N

Data  18 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50183656   

TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Csir-National Chemical Laboratory

Curated by ChEMBL
LigandPNGBDBM50183656((R)-1-(2-(dimethylamino)-1-(4-methoxyphenyl)ethyl)...)
Affinity DataIC50:  251nMAssay Description:Inhibition of human NET expressed in MDCK cells assessed as decrease in [3H]-noradrenaline reuptake after 10 mins by scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Csir-National Chemical Laboratory

Curated by ChEMBL
LigandPNGBDBM50183656((R)-1-(2-(dimethylamino)-1-(4-methoxyphenyl)ethyl)...)
Affinity DataIC50:  109nMAssay Description:Inhibition of NET (unknown origin) assessed as noradrenaline reuptakeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Csir-National Chemical Laboratory

Curated by ChEMBL
LigandPNGBDBM50183656((R)-1-(2-(dimethylamino)-1-(4-methoxyphenyl)ethyl)...)
Affinity DataIC50:  200nMAssay Description:Inhibition of noradrenaline reuptake at human recombinant noradrenaline transporterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Csir-National Chemical Laboratory

Curated by ChEMBL
LigandPNGBDBM50183656((R)-1-(2-(dimethylamino)-1-(4-methoxyphenyl)ethyl)...)
Affinity DataIC50:  251nMAssay Description:Inhibition of NET (unknown origin) assessed as noradrenaline reuptakeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Csir-National Chemical Laboratory

Curated by ChEMBL
LigandPNGBDBM50183656((R)-1-(2-(dimethylamino)-1-(4-methoxyphenyl)ethyl)...)
Affinity DataIC50:  109nMAssay Description:Inhibition of NETMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Csir-National Chemical Laboratory

Curated by ChEMBL
LigandPNGBDBM50183656((R)-1-(2-(dimethylamino)-1-(4-methoxyphenyl)ethyl)...)
Affinity DataIC50:  251nMAssay Description:Inhibition of NETMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed