BDBM50001447 CHEMBL217406::His-Lys-Thr-Asp-Ser-Phe-Val-Gly-Leu-Met-NH2::His-Lys-Thr-Asp-Ser-Phe-Val-Gly-Leu-Met-NH2(NeurokininA)
SMILES CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CCCCN)NC(=O)[C@@H](N)Cc1cnc[nH]1)[C@@H](C)O)C(C)C)C(N)=O
InChI Key InChIKey=HEAUFJZALFKPBA-JPQUDPSNSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 9 hits for monomerid = 50001447
TargetSubstance-K receptor(Homo sapiens (Human))
Creighton University School Of Medicine
Curated by ChEMBL
Creighton University School Of Medicine
Curated by ChEMBL
Affinity DataKi: 0.710nMAssay Description:The compound was tested for competition binding with [3H]NKA against the CHO cells from cloned human Tachykinin receptor 2More data for this Ligand-Target Pair
TargetSubstance-K receptor(Homo sapiens (Human))
Creighton University School Of Medicine
Curated by ChEMBL
Creighton University School Of Medicine
Curated by ChEMBL
Affinity DataKi: 1.20nMAssay Description:Displacement of [3H]GR100679 from NK2 receptor (unknown origin) expressed in CHO/T cellsMore data for this Ligand-Target Pair
Affinity DataKi: 3.70E+3nMAssay Description:Evaluated for the binding affinity against NK2 receptorMore data for this Ligand-Target Pair
Affinity DataEC50: 1.70nMAssay Description:In vitro agonistic activity against tachykinin receptor 2 of rat colon muscularis mucosae.More data for this Ligand-Target Pair
Affinity DataEC50: 0.550nMAssay Description:Allosteric modulation of rat NK2 receptor expressed in HEK293 cells assessed as increase in intracellular calcium level by spectrofluorimetryMore data for this Ligand-Target Pair
Affinity DataEC50: 64.8nMAssay Description:Allosteric modulation of rat NK2 receptor expressed in HEK293 cells assessed as cAMP production by radioimmunoassayMore data for this Ligand-Target Pair
TargetSubstance-K receptor(Homo sapiens (Human))
Creighton University School Of Medicine
Curated by ChEMBL
Creighton University School Of Medicine
Curated by ChEMBL
Affinity DataIC50: 1.70nMAssay Description:Inhibitory activity against human Tachykinin receptor 2More data for this Ligand-Target Pair
Affinity DataIC50: 1nMAssay Description:Competitive inhibition of [125I]NKA binding to hamster urinary bladder Tachykinin receptor 2More data for this Ligand-Target Pair
TargetSubstance-K receptor(Homo sapiens (Human))
Creighton University School Of Medicine
Curated by ChEMBL
Creighton University School Of Medicine
Curated by ChEMBL
Affinity DataIC50: 7.70nMAssay Description:Tested for the binding affinity to human NK2 receptor expressed in Sf-9 insect larval cells using 0.1 nM 2-[125 I] iodohistidyl neurokinin AMore data for this Ligand-Target Pair