BDBM50005480 (-)-combretastatin::(Z)-3'-hydroxy-3,4,4',5-tetramethoxystilbene::(Z)-5-(3,4,5-trimethoxystyryl)-2-methoxyphenol::(combretastatin A-4)2-Methoxy-5-[2-(3,4,5-trimethoxy-phenyl)-vinyl]-phenol::(combretastin A-4)2-Methoxy-5-[2-(3,4,5-trimethoxy-phenyl)-vinyl]-phenol::2-Methoxy-5-[(Z)-2-(3,4,5-trimethox y-phenyl)-vinyl]-phenol::2-Methoxy-5-[(Z)-2-(3,4,5-trimethoxy-phenyl)-vinyl]-phenol::2-Methoxy-5-[2-(3,4,5-trimethoxy-phenyl)-vinyl]-phenol::2-methoxy-5-(3,4,5-trimethoxystyryl)phenol::2-methoxy-5-[(Z)-2-(3,4,5-trimethoxyphenyl)vinyl]phenol::5-(3,4,5-trimethoxystyryl)-2-methoxyphenol::5-[(S)-2-Hydroxy-2-(3,4,5-trimethoxy-phenyl)-ethyl]-2-methoxy-phenol::CHEMBL67::Combrestatin A-4::Combrestatin A4::Combretastastin A-4::Combretastatin::Combretastatin-A4::Combretastin A-4::Z-Combretastatin A-4::combretastatin A-4, (CSA4)::combretastin A4

SMILES COc1ccc(\C=C/c2cc(OC)c(OC)c(OC)c2)cc1O

InChI Key InChIKey=HVXBOLULGPECHP-WAYWQWQTSA-N

Data  2 KI  102 IC50  2 Kd

PDB links: 1 PDB ID matches this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 27 hits for monomerid = 50005480   

TargetTubulin beta chain(Sus scrofa)
Csir-Indian Institute Of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM50005480((-)-combretastatin | (Z)-3'-hydroxy-3,4,4',5-tetra...)
Affinity DataIC50:  1.06E+3nMAssay Description:Inhibition of porcine brain tubulin polymerization after 1 hr by fluorescence assayMore data for this Ligand-Target Pair
TargetTubulin beta chain(Sus scrofa)
Csir-Indian Institute Of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM50005480((-)-combretastatin | (Z)-3'-hydroxy-3,4,4',5-tetra...)
Affinity DataIC50:  4.00E+3nMAssay Description:In vitro tubulin polymerization-inhibitory activity.More data for this Ligand-Target Pair
TargetTubulin beta chain(Sus scrofa)
Csir-Indian Institute Of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM50005480((-)-combretastatin | (Z)-3'-hydroxy-3,4,4',5-tetra...)
Affinity DataIC50:  1.10E+3nMAssay Description:Inhibition of pig brain tubulin polymerization in presence of GTP by spectrophotometric analysisMore data for this Ligand-Target Pair
TargetTubulin beta chain(Sus scrofa)
Csir-Indian Institute Of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM50005480((-)-combretastatin | (Z)-3'-hydroxy-3,4,4',5-tetra...)
Affinity DataIC50:  520nMAssay Description:Inhibition of porcine brain tubulin polymerization assessed as decrease in fluorescence intensity measured every 60 sec for 90 mins in presence of GT...More data for this Ligand-Target Pair
TargetTubulin beta chain(Sus scrofa)
Csir-Indian Institute Of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM50005480((-)-combretastatin | (Z)-3'-hydroxy-3,4,4',5-tetra...)
Affinity DataIC50:  1.60E+3nMAssay Description:Inhibition of pig brain tubulin polymerization by spectrophotometric methodMore data for this Ligand-Target Pair
TargetTubulin beta chain(Sus scrofa)
Csir-Indian Institute Of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM50005480((-)-combretastatin | (Z)-3'-hydroxy-3,4,4',5-tetra...)
Affinity DataIC50:  600nMAssay Description:Inhibition of pig brain tubulin polymerizationMore data for this Ligand-Target Pair
TargetTubulin beta chain(Sus scrofa)
Csir-Indian Institute Of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM50005480((-)-combretastatin | (Z)-3'-hydroxy-3,4,4',5-tetra...)
Affinity DataIC50:  1.32E+3nMAssay Description:Inhibition of porcine brain tubulin polymerization after 30 mins by spectrophotometryMore data for this Ligand-Target Pair
TargetTubulin beta chain(Sus scrofa)
Csir-Indian Institute Of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM50005480((-)-combretastatin | (Z)-3'-hydroxy-3,4,4',5-tetra...)
Affinity DataIC50:  600nMAssay Description:Inhibition of pig tubulin polymerizationMore data for this Ligand-Target Pair
TargetTubulin beta chain(Sus scrofa)
Csir-Indian Institute Of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM50005480((-)-combretastatin | (Z)-3'-hydroxy-3,4,4',5-tetra...)
Affinity DataIC50:  1.00E+3nMAssay Description:Inhibition of pig brain tubulin assembly preincubated for 15 mins followed by GTP addition measured after 20 mins by spectrophotometric analysis in p...More data for this Ligand-Target Pair
TargetTubulin beta chain(Sus scrofa)
Csir-Indian Institute Of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM50005480((-)-combretastatin | (Z)-3'-hydroxy-3,4,4',5-tetra...)
Affinity DataIC50:  4.50E+3nMAssay Description:Inhibition of porcine brain tubulin polymerization by turbidity assayMore data for this Ligand-Target Pair
TargetTubulin beta chain(Sus scrofa)
Csir-Indian Institute Of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM50005480((-)-combretastatin | (Z)-3'-hydroxy-3,4,4',5-tetra...)
Affinity DataIC50:  1.77E+3nMAssay Description:Inhibition of porcine brain tubulin assembly measured every 1 min for 60 mins by turbidimetric analysisMore data for this Ligand-Target Pair
TargetTubulin beta chain(Sus scrofa)
Csir-Indian Institute Of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM50005480((-)-combretastatin | (Z)-3'-hydroxy-3,4,4',5-tetra...)
Affinity DataIC50:  2.20E+3nMAssay Description:Inhibition of pig tubulin polymerization by spectrophotometryMore data for this Ligand-Target Pair
TargetTubulin beta chain(Sus scrofa)
Csir-Indian Institute Of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM50005480((-)-combretastatin | (Z)-3'-hydroxy-3,4,4',5-tetra...)
Affinity DataIC50:  3.90E+3nMAssay Description:Inhibition of pig brain tubulin polymerization at 37 degC by turbidimetry analysisMore data for this Ligand-Target Pair
TargetTubulin beta chain(Sus scrofa)
Csir-Indian Institute Of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM50005480((-)-combretastatin | (Z)-3'-hydroxy-3,4,4',5-tetra...)
Affinity DataIC50:  600nMAssay Description:Inhibition of porcine brain tubulin polymerization after 60 minsMore data for this Ligand-Target Pair
TargetTubulin beta chain(Sus scrofa)
Csir-Indian Institute Of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM50005480((-)-combretastatin | (Z)-3'-hydroxy-3,4,4',5-tetra...)
Affinity DataIC50:  4.22E+3nMAssay Description:Inhibition of pig brain tubulin polymerization by spectrophotometric analysisMore data for this Ligand-Target Pair
TargetTubulin beta chain(Sus scrofa)
Csir-Indian Institute Of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM50005480((-)-combretastatin | (Z)-3'-hydroxy-3,4,4',5-tetra...)
Affinity DataIC50:  1.87E+3nMAssay Description:Inhibition of porcine brain tubulin polymerization measured at 1 min interval for 1 hr by fluorescence plate reader assayMore data for this Ligand-Target Pair
TargetTubulin beta chain(Sus scrofa)
Csir-Indian Institute Of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM50005480((-)-combretastatin | (Z)-3'-hydroxy-3,4,4',5-tetra...)
Affinity DataIC50:  2.53E+3nMAssay Description:Inhibition of porcine brain tubulin polymerization measured every 2 mins for 60 mins by spectrophotometric analysisMore data for this Ligand-Target Pair
TargetTubulin beta chain(Sus scrofa)
Csir-Indian Institute Of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM50005480((-)-combretastatin | (Z)-3'-hydroxy-3,4,4',5-tetra...)
Affinity DataIC50:  2.48E+3nMAssay Description:Inhibition of porcine brain tubulin polymerization incubated for 60 mins by fluorescence-based assayMore data for this Ligand-Target Pair
TargetTubulin beta chain(Sus scrofa)
Csir-Indian Institute Of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM50005480((-)-combretastatin | (Z)-3'-hydroxy-3,4,4',5-tetra...)
Affinity DataIC50:  2.18E+3nMAssay Description:Inhibition of porcine brain tubulin polymerizationMore data for this Ligand-Target Pair
TargetTubulin beta chain(Sus scrofa)
Csir-Indian Institute Of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM50005480((-)-combretastatin | (Z)-3'-hydroxy-3,4,4',5-tetra...)
Affinity DataIC50:  2.18E+3nMAssay Description:Inhibition of porcine brain tubulin polymerizationMore data for this Ligand-Target Pair
TargetTubulin beta chain(Sus scrofa)
Csir-Indian Institute Of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM50005480((-)-combretastatin | (Z)-3'-hydroxy-3,4,4',5-tetra...)
Affinity DataIC50:  2.12E+3nMAssay Description:Inhibition of porcine brain tubulin polymerization preincubated for 30 mins and measured every 2 mins for 60 mins by spectrophotometric analysisMore data for this Ligand-Target Pair
TargetTubulin beta chain(Sus scrofa)
Csir-Indian Institute Of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM50005480((-)-combretastatin | (Z)-3'-hydroxy-3,4,4',5-tetra...)
Affinity DataIC50:  2.12E+3nMAssay Description:Inhibition of porcine brain tubulin polymerization preincubated for 30 mins and measured every 2 mins for 60 mins by spectrophotometric analysisMore data for this Ligand-Target Pair
TargetTubulin beta chain(Sus scrofa)
Csir-Indian Institute Of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM50005480((-)-combretastatin | (Z)-3'-hydroxy-3,4,4',5-tetra...)
Affinity DataIC50:  1.30E+3nMAssay Description:Inhibition of pig brain tubulin polymerization by spectrophotometeric analysisMore data for this Ligand-Target Pair
TargetTubulin beta chain(Sus scrofa)
Csir-Indian Institute Of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM50005480((-)-combretastatin | (Z)-3'-hydroxy-3,4,4',5-tetra...)
Affinity DataIC50:  1.00E+3nMAssay Description:Inhibition of pig brain tubulin polymerization by spectrometric methodMore data for this Ligand-Target Pair
TargetTubulin beta chain(Sus scrofa)
Csir-Indian Institute Of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM50005480((-)-combretastatin | (Z)-3'-hydroxy-3,4,4',5-tetra...)
Affinity DataIC50:  1.00E+3nMAssay Description:Inhibition of pig brain tubulin polymerization by spectrophotometric methodMore data for this Ligand-Target Pair
TargetTubulin beta chain(Sus scrofa)
Csir-Indian Institute Of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM50005480((-)-combretastatin | (Z)-3'-hydroxy-3,4,4',5-tetra...)
Affinity DataIC50:  2.61E+3nMAssay Description:Inhibition of porcine brain tubulin assessed as changes in the fluorescence intensity measured for 60 mins by cell free tubulin polymerization assayMore data for this Ligand-Target Pair
TargetTubulin beta chain(Sus scrofa)
Csir-Indian Institute Of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM50005480((-)-combretastatin | (Z)-3'-hydroxy-3,4,4',5-tetra...)
Affinity DataKd:  3.51E+3nMAssay Description:Binding affinity to porcine brain tubulin assessed as changes in the fluorescence incubated for 10 mins tryptophan-based binding assayMore data for this Ligand-Target Pair