BDBM127782 US10251889, Example 155::US10758542, Example 155::US8791123, 155::US9782415, Example 155::US9796724, Example 155

SMILES COc1ncc(F)cc1[C@H]1CCCN1c1ccn2ncc(C(=O)NCCO)c2n1

InChI Key InChIKey=YLAKIDRGVDYWAA-OAHLLOKOSA-N

Data  10 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 127782   

TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Array Biopharma

US Patent
LigandPNGBDBM127782(US10251889, Example 155 | US10758542, Example 155 ...)
Affinity DataIC50: >1.00E+3nMAssay Description:Compounds of Formula I were screened for their ability to inhibit Jak2 using the general enzyme inhibition assay method, in which the assay mixture c...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Array Biopharma

US Patent
LigandPNGBDBM127782(US10251889, Example 155 | US10758542, Example 155 ...)
Affinity DataIC50: >1.00E+3nMAssay Description:Compounds of Formula I were screened for their ability to inhibit Jak2 using the general enzyme inhibition assay method, in which the assay mixture c...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Array Biopharma

US Patent
LigandPNGBDBM127782(US10251889, Example 155 | US10758542, Example 155 ...)
Affinity DataIC50:  0.200nMAssay Description:Compounds of Formula I were screened for their ability to inhibit Jak2 using the general enzyme inhibition assay method, in which the assay mixture c...More data for this Ligand-Target Pair
In DepthDetails US Patent