BDBM50236232 CHEMBL4062668::US11186582, Example 309
SMILES Cc1cc([C@@H]2CN(CC(F)(F)C2)C(=O)c2cc(C)c(F)c(F)c2)n2ncnc2n1
InChI Key InChIKey=GUUGIMRNACHKSC-ZDUSSCGKSA-N
Data 2 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 2 hits for monomerid = 50236232
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Dart Neuroscience (Cayman)
US Patent
Dart Neuroscience (Cayman)
US Patent
Affinity DataIC50: <100nMAssay Description:An IMAP TR-FRET-based phosphodiesterase assay was developed using the PDE2A isoform. IMAP technology is based on high-affinity binding of phosphate b...More data for this Ligand-Target Pair
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Dart Neuroscience (Cayman)
US Patent
Dart Neuroscience (Cayman)
US Patent
Affinity DataIC50: 62nMAssay Description:Inhibition of human full length GST-tagged PDE2a using FAM-labeled cAMP as substrate preincubated for 5 mins followed by substrate addition measured ...More data for this Ligand-Target Pair