BDBM50005711 CHEBI:46024::GNF-Pf-1011::TRICHOSTATIN::Trichostatin A::Trichostatin A (TSA)::US10011611, Trichostatin A::US10722597, Compound Trichostatin::US11535598, Compound Trichostatin A::US20230322747, Compound trichostatin A::US9265734, TSA

SMILES C[C@H](\C=C(/C)\C=C\C(=O)NO)C(=O)c1ccc(cc1)N(C)C

InChI Key InChIKey=RTKIYFITIVXBLE-QEQCGCAPSA-N

Data  30 KI  298 IC50  6 Kd  1 EC50  1 ITC

PDB links: 14 PDB IDs match this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50005711   

TargetHistone deacetylase 6(Human)
University of Regensburg

Curated by ChEMBL
LigandPNGBDBM50005711(CHEBI:46024 | GNF-Pf-1011 | TRICHOSTATIN | Trichos...)
Affinity DataEC50:  5.20nMAssay Description:Inhibition of HDAC6 in human HeLa cells assessed as inhibition of tubulin deacetylation incubated for overnight by cELISAMore data for this Ligand-Target Pair

Activity Spreadsheet -- ITC Data from BindingDB

Found 1 hit for monomerid = 50005711   

CellHistone deacetylase 8 (HDAC8)(Human)
North Dakota State University

SyringePNGBDBM50005711(CHEBI:46024 | GNF-Pf-1011 | TRICHOSTATIN | Trichos...)
ITC DataΔG°: -8.60kcal/mole −TΔS°: 0.0179kcal/mole ΔH°: -8.80kcal/mole logk: 3.36E+6
pH: 7.5 T: -248.15°C