BDBM50152124 CHEMBL3782004

SMILES Nc1nc(NC2CC2)cc(n1)-c1cccc(Cl)c1Cl

InChI Key InChIKey=PNMYJIOQIAEYQL-UHFFFAOYSA-N

Data  8 IC50  1 Kd  2 EC50

PDB links: 5 PDB IDs match this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50152124   

TargetOxidized purine nucleoside triphosphate hydrolase(Homo sapiens (Human))
Md Anderson Cancer Center

Curated by ChEMBL
LigandPNGBDBM50152124(CHEMBL3782004)
Affinity DataEC50:  126nMAssay Description:Binding affinity to MTH1 in human K562 cells assessed as concentration required to achieve half of the maximal stabilization of protein at 54 degC af...More data for this Ligand-Target Pair
TargetOxidized purine nucleoside triphosphate hydrolase(Homo sapiens (Human))
Md Anderson Cancer Center

Curated by ChEMBL
LigandPNGBDBM50152124(CHEMBL3782004)
Affinity DataEC50:  10nMAssay Description:Binding affinity to MTH1 in human K562 cells assessed as thermal stabilization preincubated for 30 mins followed by heating at 52 degree C for 3 mins...More data for this Ligand-Target Pair