BDBM21278 5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-N-(piperidin-1-yl)-1H-pyrazole-3-carboxamide::Acomplia::CHEMBL111::CHEMBL558598::RIMONABANT HYDROCHLORIDE::Rimonabant::SR 141716A::SR141716::SR141716A::[3H]Rimonabant::[3H]SR141716A
SMILES Cc1c(nn(c1-c1ccc(Cl)cc1)-c1ccc(Cl)cc1Cl)C(=O)NN1CCCCC1
InChI Key InChIKey=JZCPYUJPEARBJL-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 79 hits for monomerid = 21278
TargetCannabinoid receptor 1(Homo sapiens (Human))
National Institute Of Mental Health
Curated by ChEMBL
National Institute Of Mental Health
Curated by ChEMBL
Affinity DataIC50: 11.2nMAssay Description:Antagonist activity against human CB1 receptorMore data for this Ligand-Target Pair
TargetCannabinoid receptor 1(Homo sapiens (Human))
National Institute Of Mental Health
Curated by ChEMBL
National Institute Of Mental Health
Curated by ChEMBL
Affinity DataIC50: 3nMpH: 7.4 T: 2°CAssay Description:A GTP-gamma-S CB1 functional assay was used to assess the potency of the pyrazine derivatives. [35S]GTP-gamma-S binding assays were performed at 30 d...More data for this Ligand-Target Pair
TargetCannabinoid receptor 1(Cricetulus griseus (Chinese hamster))
Nanchang University School of Pharmaceutical Science
Nanchang University School of Pharmaceutical Science
Affinity DataIC50: 4.72nMAssay Description:The target compounds were evaluated using a binding assay towards the CB1 receptor expressed on the membranes of Chinese hamster ovarian (CHO) cells....More data for this Ligand-Target Pair
TargetCannabinoid receptor 1(Homo sapiens (Human))
National Institute Of Mental Health
Curated by ChEMBL
National Institute Of Mental Health
Curated by ChEMBL
Affinity DataIC50: 6.20nMAssay Description:Inhibitory concentration tested against human Cannabinoid receptor 1 (hCB1)More data for this Ligand-Target Pair
TargetCannabinoid receptor 1(Homo sapiens (Human))
National Institute Of Mental Health
Curated by ChEMBL
National Institute Of Mental Health
Curated by ChEMBL
Affinity DataIC50: 6nMAssay Description:Inhibitory concentration against human recombinant cannabinoid receptor type 1 expressed in Chinese Hamster Ovary (CHO) cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 9.80E+3nMAssay Description:Antagonist activity at CB2 receptor (unknown origin) expressed in CHO cells up to 10 uM incubated for 10 mins prior to CP55940 addition by calcium mo...More data for this Ligand-Target Pair
TargetCannabinoid receptor 1(Homo sapiens (Human))
National Institute Of Mental Health
Curated by ChEMBL
National Institute Of Mental Health
Curated by ChEMBL
Affinity DataIC50: 13nMAssay Description:Antagonist activity at CB1 receptor (unknown origin) expressed in CHO cells up to 10 uM incubated for 10 mins prior to CP55940 addition by calcium mo...More data for this Ligand-Target Pair
TargetCannabinoid receptor 1(Homo sapiens (Human))
National Institute Of Mental Health
Curated by ChEMBL
National Institute Of Mental Health
Curated by ChEMBL
Affinity DataIC50: 14nMAssay Description:Antagonist activity against CB1R (unknown origin) CHO cells stably expressing Galpha16 assessed as inhibition of CP55940-induced increase in intracel...More data for this Ligand-Target Pair
Affinity DataIC50: 9.10E+3nMAssay Description:Antagonist activity against CB2R (unknown origin) CHO cells stably expressing Galpha16 assessed as inhibition of CP55940-induced increase in intracel...More data for this Ligand-Target Pair
Affinity DataIC50: 603nMAssay Description:Displacement of [3H]CP55940 from human recombinant CB2 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
TargetCannabinoid receptor 1(Homo sapiens (Human))
National Institute Of Mental Health
Curated by ChEMBL
National Institute Of Mental Health
Curated by ChEMBL
Affinity DataIC50: 6.10nMAssay Description:Displacement of [3H]CP55940 from human recombinant CB1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 3.92E+3nMAssay Description:Displacement of [3H]SR141716A from CB1 receptor in Sprague-Dawley rat cerebellum membraneMore data for this Ligand-Target Pair
Affinity DataIC50: 1.90nMAssay Description:Displacement of [3H]CP55940 from CB1 receptor in Sprague-Dawley rat cerebella membraneMore data for this Ligand-Target Pair
Affinity DataIC50: 1.76E+3nMAssay Description:Displacement of [3H]WIN55212-2 from human CB2 receptor expressed in CHOK1 cellsMore data for this Ligand-Target Pair
TargetCannabinoid receptor 1(Homo sapiens (Human))
National Institute Of Mental Health
Curated by ChEMBL
National Institute Of Mental Health
Curated by ChEMBL
Affinity DataIC50: 120nMAssay Description:Antagonist activity at human CB1 receptor expressed in CHOK1 cells by luciferase assayMore data for this Ligand-Target Pair
TargetCannabinoid receptor 1(Homo sapiens (Human))
National Institute Of Mental Health
Curated by ChEMBL
National Institute Of Mental Health
Curated by ChEMBL
Affinity DataIC50: 2.20nMAssay Description:Binding affinity to human CB1 receptor by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
Affinity DataIC50: 4.57E+3nMAssay Description:Binding affinity to human CB2 receptor by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
TargetCannabinoid receptor 1(Homo sapiens (Human))
National Institute Of Mental Health
Curated by ChEMBL
National Institute Of Mental Health
Curated by ChEMBL
Affinity DataIC50: 15nMAssay Description:Displacement of [3H]CP55940 from human CB1 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 1.94E+3nMAssay Description:Displacement of [3H]CP55940 from human CB2 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 1.76E+3nMAssay Description:Displacement of [3H]WIN55212-2 from human CB2 receptor expressed in CHOK1 cells by liquid scintillation spectrometryMore data for this Ligand-Target Pair
Affinity DataIC50: 4.53nMAssay Description:Displacement of [3H]CP55940 from CB1 receptor in Sprague-Dawley rat cerebellum by liquid scintillation spectrometryMore data for this Ligand-Target Pair
Affinity DataIC50: 5nMAssay Description:Displacement of [3H]CP55940 from CB1 receptor in Sprague-Dawley rat cerebellar membraneMore data for this Ligand-Target Pair
Affinity DataIC50: 1.76E+3nMAssay Description:Displacement of [3H]WIN-55212-2 from human CB2 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 5nMAssay Description:Displacement of [3H]CP55,940 from cannabinoid CB1 receptor in Sprague-Dawley rat cerebellar membrane by liquid scintillation spectrometryMore data for this Ligand-Target Pair
Affinity DataIC50: 1.76E+3nMAssay Description:Displacement of [3H]WIN55,212-2 from human recombinant cannabinoid CB2 receptor expressed in CHOK1 cells by liquid scintillation spectrometryMore data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+3nMAssay Description:Displacement of [3H]WIN55,212-2 from human CB2 receptor expressed in CHO-K1 cells by liquid scintillation countingMore data for this Ligand-Target Pair
Affinity DataIC50: 5.20nMAssay Description:Displacement of [3H]WIN55,212-2 from CB1 receptor in rat cerebellar membrane by liquid scintillation countingMore data for this Ligand-Target Pair
TargetCannabinoid receptor 1(Homo sapiens (Human))
National Institute Of Mental Health
Curated by ChEMBL
National Institute Of Mental Health
Curated by ChEMBL
Affinity DataIC50: 15nMAssay Description:Displacement of [3H]CP55940 from human CB1 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 1.90nMAssay Description:Displacement of [3H]CP55940 from human CB2 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 5nMAssay Description:Displacement of [3H]CP55940 from CB1R in Sprague-Dawley rat cerebellar membraneMore data for this Ligand-Target Pair
TargetCannabinoid receptor 1(Homo sapiens (Human))
National Institute Of Mental Health
Curated by ChEMBL
National Institute Of Mental Health
Curated by ChEMBL
Affinity DataIC50: 13.2nMAssay Description:Displacement of [3H]CP55940 from human recombinant CB1R expressed in HEK293 cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 1.63E+3nMAssay Description:Displacement of [3H]CP55940 from human recombinant CB2R expressed in HEK293 cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 5nMAssay Description:Displacement of [3H]CP55940 from cannabinoid CB1 receptor in Sprague-Dawley rat cerebellar membrane by liquid scintillation spectrometryMore data for this Ligand-Target Pair
Affinity DataIC50: 5nMAssay Description:Displacement of [3H]CP55,940 from CB1 receptor in Sprague-Dawley rat cerebellar membraneMore data for this Ligand-Target Pair
Affinity DataIC50: 92.5nMAssay Description:Binding affinity to human CB2 receptor expressed in CHO cells by luciferase reporter gene assayMore data for this Ligand-Target Pair
Affinity DataIC50: 1.76E+3nMAssay Description:Displacement of [3H]WIN552122 from human CB2 receptor expressed in CHOK1 cellsMore data for this Ligand-Target Pair
TargetCannabinoid receptor 1(Homo sapiens (Human))
National Institute Of Mental Health
Curated by ChEMBL
National Institute Of Mental Health
Curated by ChEMBL
Affinity DataIC50: 2.10nMAssay Description:Agonist activity at human CB1 receptor assessed as stimulation of [35S]GTPgammaS bindingMore data for this Ligand-Target Pair
TargetCannabinoid receptor 1(Homo sapiens (Human))
National Institute Of Mental Health
Curated by ChEMBL
National Institute Of Mental Health
Curated by ChEMBL
Affinity DataIC50: 4.5nMAssay Description:Antagonist activity at human CB1 receptor expressed in CHO-K1 cells assessed as inhibition of CP55940-induced GTPgammaS bindingMore data for this Ligand-Target Pair
TargetCannabinoid receptor 1(Homo sapiens (Human))
National Institute Of Mental Health
Curated by ChEMBL
National Institute Of Mental Health
Curated by ChEMBL
Affinity DataIC50: 2.90nMAssay Description:Inverse agonist activity at human CB1 receptor expressed in CHO-K1 cells by GTPgammaS binding assayMore data for this Ligand-Target Pair
TargetCannabinoid receptor 1(Homo sapiens (Human))
National Institute Of Mental Health
Curated by ChEMBL
National Institute Of Mental Health
Curated by ChEMBL
Affinity DataIC50: 5.10nMAssay Description:Displacement of [3H]CP55940 from human CB1 receptor expressed in COS7 cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 4.53nMAssay Description:Displacement of [3H]CP55,940 from CB1 receptor in Sprague-Dawley rat cerebellar membraneMore data for this Ligand-Target Pair
Affinity DataIC50: 1.76E+3nMAssay Description:Displacement of [3H]WIN55,212-2 from human recombinant CB2 receptor expressed in CHO-K1 cell membraneMore data for this Ligand-Target Pair
TargetCannabinoid receptor 1(Homo sapiens (Human))
National Institute Of Mental Health
Curated by ChEMBL
National Institute Of Mental Health
Curated by ChEMBL
Affinity DataIC50: 108nMAssay Description:Inverse agonist activity at human recombinant CB1 receptor expressed in CHO cells by luciferase reporter gene assayMore data for this Ligand-Target Pair
TargetCannabinoid receptor 1(Homo sapiens (Human))
National Institute Of Mental Health
Curated by ChEMBL
National Institute Of Mental Health
Curated by ChEMBL
Affinity DataIC50: 4.5nMAssay Description:Antagonist activity at human recombinant CB1 receptor expressed in CHO-K1 cells assessed as inhibition of CP55940-stimulated GTPgammaS bindingMore data for this Ligand-Target Pair
TargetCannabinoid receptor 1(Homo sapiens (Human))
National Institute Of Mental Health
Curated by ChEMBL
National Institute Of Mental Health
Curated by ChEMBL
Affinity DataIC50: 3.20nMAssay Description:Antagonist activity at human cannabinoid CB1 receptor expressed in CHO cells coexpressing Galpha15/16 assessed as inhibition of CP55940-induced Ca2+ ...More data for this Ligand-Target Pair
Affinity DataIC50: 2.5nMAssay Description:Binding affinity to CB1 receptor in rat brain synaptosomal membranesMore data for this Ligand-Target Pair
Affinity DataIC50: 5.30nMAssay Description:Inhibition of CYP2C9 in human liver microsomes after 30 minsMore data for this Ligand-Target Pair
Affinity DataIC50: >20nMAssay Description:Inhibition of CYP2D6 in human liver microsomes after 30 minsMore data for this Ligand-Target Pair
Affinity DataIC50: >20nMAssay Description:Inhibition of CYP3A4 in human liver microsomes after 30 minsMore data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Green Cross
Curated by ChEMBL
Green Cross
Curated by ChEMBL
Affinity DataIC50: 4.80E+3nMAssay Description:Inhibition of human ERG at holding potential of -80 mV to +40 mVMore data for this Ligand-Target Pair