BDBM50240975 CHEMBL4084907

SMILES Nc1cc(c(cn1)-c1nc(nc(n1)N1CCOCC1)N1CCOCC1)C(F)(F)F

InChI Key InChIKey=ADGGYDAFIHSYFI-UHFFFAOYSA-N

Data  8 KI  16 IC50  9 Kd

PDB links: 1 PDB ID matches this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 16 hits for monomerid = 50240975   

TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
University of Basel

Curated by ChEMBL
LigandPNGBDBM50240975(CHEMBL4084907)
Affinity DataIC50:  89nMAssay Description:Displacement of [3H]baclofen from gamma-aminobutyric-acid B receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Homo sapiens (Human))
University of Basel

Curated by ChEMBL
LigandPNGBDBM50240975(CHEMBL4084907)
Affinity DataIC50:  451nMAssay Description:Displacement of [3H]baclofen from gamma-aminobutyric-acid B receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform(Homo sapiens (Human))
University of Basel

Curated by ChEMBL
LigandPNGBDBM50240975(CHEMBL4084907)
Affinity DataIC50:  661nMAssay Description:Displacement of [3H]baclofen from gamma-aminobutyric-acid B receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform(Homo sapiens (Human))
University of Basel

Curated by ChEMBL
LigandPNGBDBM50240975(CHEMBL4084907)
Affinity DataIC50:  708nMAssay Description:Inhibition of PI3Kgamma (unknown origin)More data for this Ligand-Target Pair
LigandPNGBDBM50240975(CHEMBL4084907)
Affinity DataIC50:  33nMAssay Description:Inhibition of PI3Kalpha (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
University of Basel

Curated by ChEMBL
LigandPNGBDBM50240975(CHEMBL4084907)
Affinity DataIC50:  205nMAssay Description:Inhibition of mTOR in human A2058 cells assessed as reduction in phosphorylation of S6 at ser235/236 residues after 1 hr by in-cell Western methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTarget of rapamycin complex 2 subunit MAPKAP1(Homo sapiens)
University of Basel

Curated by ChEMBL
LigandPNGBDBM50240975(CHEMBL4084907)
Affinity DataIC50:  139nMAssay Description:Inhibition of mTORC2 in human A2058 cells assessed as reduction in PKB phosphorylation at S473 residues incubated for 1 hr by Western blot analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTarget of rapamycin complex subunit LST8(Homo sapiens)
University of Basel

Curated by ChEMBL
LigandPNGBDBM50240975(CHEMBL4084907)
Affinity DataIC50:  205nMAssay Description:Inhibition of mTORC1 in human A2058 cells assessed as reduction in ribosomal protein S6 phosphorylation at Ser235/236 residues incubated for 1 hr by ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
University of Basel

Curated by ChEMBL
LigandPNGBDBM50240975(CHEMBL4084907)
Affinity DataIC50:  89nMAssay Description:Inhibition of mTOR (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
LigandPNGBDBM50240975(CHEMBL4084907)
Affinity DataIC50:  33nMAssay Description:Inhibition of PI3Kalpha (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
LigandPNGBDBM50240975(CHEMBL4084907)
Affinity DataIC50:  33nMAssay Description:Inhibition of PI3Kalpha (unknown origin) expressed in baculovirus expression system using L-alpha-phosphatidylinositol as substrate by luminescence a...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform(Homo sapiens (Human))
University of Basel

Curated by ChEMBL
LigandPNGBDBM50240975(CHEMBL4084907)
Affinity DataIC50:  661nMAssay Description:Inhibition of PI3Kbeta (unknown origin) expressed in baculovirus expression system using L-alpha-phosphatidylinositol as substrate by luminescence as...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Homo sapiens (Human))
University of Basel

Curated by ChEMBL
LigandPNGBDBM50240975(CHEMBL4084907)
Affinity DataIC50:  708nMAssay Description:Inhibition of PI3Kdelta (unknown origin) expressed in baculovirus expression system using L-alpha-phosphatidylinositol as substrate by luminescence a...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform(Homo sapiens (Human))
University of Basel

Curated by ChEMBL
LigandPNGBDBM50240975(CHEMBL4084907)
Affinity DataIC50:  451nMAssay Description:Inhibition of PI3Kgamma (unknown origin) expressed in baculovirus expression system using L-alpha-phosphatidylinositol as substrate by luminescence a...More data for this Ligand-Target Pair
TargetPhosphatidylinositol 3-kinase catalytic subunit type 3(Homo sapiens (Human))
University of Basel

Curated by ChEMBL
LigandPNGBDBM50240975(CHEMBL4084907)
Affinity DataIC50:  8.49E+3nMAssay Description:Inhibition of VPS34 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA-dependent protein kinase catalytic subunit(Homo sapiens (Human))
University of Basel

Curated by ChEMBL
LigandPNGBDBM50240975(CHEMBL4084907)
Affinity DataIC50:  8.57E+3nMAssay Description:Inhibition of DNAPK (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed