BindingDB BDBM67545 N,N-dimethyl-3-(10-phenothiazinyl)-1-propanamine;hydrochloride::N,N-dimethyl-3-phenothiazin-10-yl-propan-1-amine;hydrochloride::N,N-dimethyl-3-phenothiazin-10-ylpropan-1-amine;hydrochloride::PROMAZINE::SR-01000000228-4::US9504692, Promazine::cid_5887::dimethyl(3-phenothiazin-10-ylpropyl)amine;hydrochloride

BDBM67545 N,N-dimethyl-3-(10-phenothiazinyl)-1-propanamine;hydrochloride::N,N-dimethyl-3-phenothiazin-10-yl-propan-1-amine;hydrochloride::N,N-dimethyl-3-phenothiazin-10-ylpropan-1-amine;hydrochloride::PROMAZINE::SR-01000000228-4::US9504692, Promazine::cid_5887::dimethyl(3-phenothiazin-10-ylpropyl)amine;hydrochloride

SMILES CN(C)CCCN1c2ccccc2Sc2ccccc12

InChI Key InChIKey=ZGUGWUXLJSTTMA-UHFFFAOYSA-N

Data 21 KI 10 IC50 1 EC50

PDB links: 2 PDB IDs match this monomer.

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 67545

Glutathione S-transferase P/Mucosa-associated lymphoid tissue lymphoma translocation protein 1(Homo sapiens (Human))
Helmholtz Munich

US Patent

BDBM67545(N,N-dimethyl-3-(10-phenothiazinyl)-1-propanamine;h...)

IC50: 5.80E+3nMT: 2°CAssay Description:To screen for small molecular weight compounds that can inhibit MALT1 protease activity, recombinant GSTMALT1 was purified from E. coli to establish ...More data for this Ligand-Target Pair

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Lysine-specific histone demethylase 1A(Homo sapiens (Human))TBA

BDBM67545(N,N-dimethyl-3-(10-phenothiazinyl)-1-propanamine;h...)

IC50: 4.71E+3nMAssay Description:Inhibition of recombinant LSD1 (unknown origin) expressed in Escherichia coli BL21 (DE3) using H3K4me2 peptide as substrate incubated for 30 mins by ...More data for this Ligand-Target Pair

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Histamine H1 receptor(Homo sapiens (Human))
Mayo Clinic

Curated by PDSP K_i Database

BDBM67545(N,N-dimethyl-3-(10-phenothiazinyl)-1-propanamine;h...)

IC50: 2.45E+3nMAssay Description:Antagonist activity at H1 receptor in human HeLa cells assessed as inhibition of histamine-induced Ca2+ release by using fura-2AM-based fluorescence ...More data for this Ligand-Target Pair

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Histamine H1 receptor(RAT)
TBA

Curated by PDSP K_i Database

BDBM67545(N,N-dimethyl-3-(10-phenothiazinyl)-1-propanamine;h...)

IC50: 1.26E+3nMAssay Description:Displacement of [3H]mepyramine from histamine H1 receptor in Sprague-Dawley rat brain membrane after 2 hr by scintillation countingMore data for this Ligand-Target Pair

Reactome pathway KEGG
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NADPH oxidase 1(Homo sapiens (Human))
The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay

BDBM67545(N,N-dimethyl-3-(10-phenothiazinyl)-1-propanamine;h...)

IC50: >1.70E+4nMAssay Description:Data Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Center Affiliation: The Scripps Research Institut...More data for this Ligand-Target Pair

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Solute carrier family 22 member 1(Homo sapiens (Human))
Uppsala University

Curated by ChEMBL

BDBM67545(N,N-dimethyl-3-(10-phenothiazinyl)-1-propanamine;h...)

IC50: 1.72E+4nMAssay Description:Inhibition of 4-(4-(dimethylamino)styryl)-N-methylpyridinium uptake at human OCT1 expressed in HEK293 cells by confocal microscopyMore data for this Ligand-Target Pair

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Pleiotropic ABC efflux transporter of multiple drugs(Saccharomyces cerevisiae S288c)
Wroclaw Medical University

Curated by ChEMBL

BDBM67545(N,N-dimethyl-3-(10-phenothiazinyl)-1-propanamine;h...)

IC50: 1.13E+4nMAssay Description:Inhibition of Pdr5p-mediated rhodamine 6G transport in Saccharomyces cerevisiae MKPDR5h plasma membrane by spectrofluorometric assayMore data for this Ligand-Target Pair

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D(1A)/D(2) dopamine receptor(BOVINE)
TBA

Curated by ChEMBL

BDBM67545(N,N-dimethyl-3-(10-phenothiazinyl)-1-propanamine;h...)

IC50: 130nMAssay Description:Compound was tested for inhibition of [3H]spiperone binding in membrane preparations obtained from calf caudate.More data for this Ligand-Target Pair

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D(1A)/D(1B)/D(2)/D(3)/D(4) dopamine receptor(Rattus norvegicus (rat))
TBA

Curated by ChEMBL

BDBM67545(N,N-dimethyl-3-(10-phenothiazinyl)-1-propanamine;h...)

IC50: 1.04E+3nMAssay Description:Compound was tested for inhibition of [3H]spiperone binding in membrane preparations obtained from rat corpus striatum.More data for this Ligand-Target Pair

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Sodium channel protein type 1/2/3 subunit alpha(Homo sapiens (Human))
TBA

Curated by ChEMBL

BDBM67545(N,N-dimethyl-3-(10-phenothiazinyl)-1-propanamine;h...)

IC50: 5.40E+3nMAssay Description:Inhibition of binding of Batrachotoxinin [3H]BTX-B to high affinity sites on voltage dependent sodium channels in a vesicular preparation from guinea...More data for this Ligand-Target Pair

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Filter my 32 hits

Targets 20▿
- Histamine H1 receptor 5
- D(2) dopamine receptor 5
- Alpha-1A adrenergic receptor 2
- D(1A) dopamine receptor 2
- Muscarinic acetylcholine receptor M2 2
- Alpha-2A adrenergic receptor 2
- Pleiotropic ABC efflux transporter of multiple drugs 1
- Solute carrier family 22 member 1 1
- Glutathione S-transferase P/Mucosa-associated lymphoid tissue lymphoma translocation protein 1 1
- Beta-2 adrenergic receptor 1
- Lysine-specific histone demethylase 1A 1
- D(3) dopamine receptor 1
- 5-hydroxytryptamine receptor 2C 1
- D(1A)/D(2) dopamine receptor 1
- NADPH oxidase 1 1
- 5-hydroxytryptamine receptor 1A/1B/1D/2C 1
- Major prion protein 1
- Sodium channel protein type 1/2/3 subunit alpha 1
- D(1A)/D(1B)/D(2)/D(3)/D(4) dopamine receptor 1
- Trypanothione reductase 1
Publications 16▿
- Ann N Y Acad Sci 537: 435-42 (1988) 7
- Eur J Pharmacol 103: 197-204 (1984) 5
- J Neuropsychiatry Clin Neurosci 8: 223-6 (1996) 2
- J Med Chem 23: 938-41 (1980) 2
- J Med Chem 55: 7054-60 (2012) 2
- J Pharmacol Exp Ther 315: 1278-87 (2005) 2
- Mol Pharmacol 12: 800-12 (1976) 2
- J Med Chem 41: 148-56 (1998) 1
- US Patent US9504692 (2016) 1
- Antimicrob Agents Chemother 53: 1516-27 (2009) 1
- Mol Pharmacol 12: 568-80 (1976) 1
- J Med Chem 28: 381-8 (1985) 1
- PubChem Bioassay (2010) 1
- Proc Natl Acad Sci U S A 75: 6290-4 (1978) 1
- J Med Chem 51: 5932-42 (2008) 1
- J Med Chem 46: 3563-4 (2003) 1
Institutions 10▿
- Mayo Clinic 12
- TBA 9
- Acadia Pharmaceuticals 2
- University Of Oxford 2
- Wroclaw Medical University 1
- Institut F£R Molekularbiologie Und Biophysik 1
- University of Manchester 1
- Uppsala University 1
- The Scripps Research Institute Molecular Screening Center 1
- Helmholtz Munich 1
Affinity: 2 to 5.9E+4 nM▿
- Ki 21
- IC50 10
- EC50 1
- Affinity ≤ nM
Xtal structures: 1
Docked structures: 0
Catalog Cmpds: 1