BDBM50246769 CHEMBL4064608

SMILES C1CC(CCO1)c1c[nH]c2ncnc(N[C@H]3CC[C@@H](CC3)N3CCOCC3)c12

InChI Key InChIKey=DJVYXMINSBMUHH-QAQDUYKDSA-N

Data  22 IC50  4 Kd

PDB links: 1 PDB ID matches this monomer.

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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50246769   

TargetInterleukin-1 receptor-associated kinase 4(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50246769(CHEMBL4064608)
Affinity DataKd:  0.700nMAssay Description:Binding affinity to wild type human IRAK4 (M1 to S460) expressed in mammalian expression systemMore data for this Ligand-Target Pair
TargetInterleukin-1 receptor-associated kinase-like 2(Homo sapiens)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50246769(CHEMBL4064608)
Affinity DataKd:  170nMAssay Description:Binding affinity wild type human IRAK2 (T180 to T519) expressed in mammalian expression systemMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterleukin-1 receptor-associated kinase 3(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50246769(CHEMBL4064608)
Affinity DataKd:  93nMAssay Description:Binding affinity wild type human IRAK3 (V147 to E596) expressed in bacterial expression systemMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterleukin-1 receptor-associated kinase 1(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50246769(CHEMBL4064608)
Affinity DataKd:  26nMAssay Description:Binding affinity to wild type human IRAK1 (R194 to S712) expressed in mammalian expression systemMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed