BDBM50130880 CHEMBL407196::NT(1-13)::neurotensin::pGlu-Leu-Tyr-Glu-Asn-Lys-Pro-Arg-Arg-Pro-Tyr-Ile-Leu::pGlu-Leu-Tyr-Glu-Asn-Lys-Pro-Arg-Arg-Pro-Tyr-Ile-Leu-OH

SMILES [#6]-[#6]-[#6@H](-[#6])-[#6@H](-[#7]-[#6](=O)-[#6@H](-[#6]-c1ccc(-[#8])cc1)-[#7]-[#6](=O)-[#6@@H]-1-[#6]-[#6]-[#6]-[#7]-1-[#6](=O)-[#6@H](-[#6]-[#6]-[#6]\[#7]=[#6](/[#7])-[#7])-[#7]-[#6](=O)-[#6@H](-[#6]-[#6]-[#6]\[#7]=[#6](\[#7])-[#7])-[#7]-[#6](=O)-[#6@@H]-1-[#6]-[#6]-[#6]-[#7]-1-[#6](=O)-[#6@H](-[#6]-[#6]-[#6]-[#6]-[#7])-[#7]-[#6](=O)-[#6@H](-[#6]-[#6](-[#7])=O)-[#7]-[#6](=O)-[#6@H](-[#6]-[#6]-[#6](-[#8])=O)-[#7]-[#6](=O)-[#6@H](-[#6]-c1ccc(-[#8])cc1)-[#7]-[#6](=O)-[#6@H](-[#6]-[#6](-[#6])-[#6])-[#7]-[#6](=O)-[#6@@H]-1-[#6]-[#6]-[#6](=O)-[#7]-1)-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6](-[#6])-[#6])-[#6](-[#8])=O

InChI Key InChIKey=PCJGZPGTCUMMOT-ISULXFBGSA-N

Data  15 KI  15 IC50  2 Kd  9 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 15 hits for monomerid = 50130880   

TargetNeurotensin receptor type 1(MOUSE)
TBA

Curated by ChEMBL
LigandPNGBDBM50130880(CHEMBL407196 | NT(1-13) | neurotensin | pGlu-Leu-T...)
Affinity DataKi:  0.170nMAssay Description:Concentration producing half maximal inhibition of specific binding of [125I]-Tyr3-NT(1-13) to NT receptor in neonatal mouse whole brain (minus cereb...More data for this Ligand-Target Pair
In DepthDetails Article
TargetNeurotensin receptor type 1(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50130880(CHEMBL407196 | NT(1-13) | neurotensin | pGlu-Leu-T...)
Affinity DataKi:  0.270nMAssay Description:Binding affinity to human NTS1 receptor by radioligand displacement assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeurotensin receptor type 1(Rattus norvegicus)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50130880(CHEMBL407196 | NT(1-13) | neurotensin | pGlu-Leu-T...)
Affinity DataKi:  1.10nMAssay Description:Displacement of [125I]neurotensin from rat NTS1 receptor expressed in CHO-K1 cells by competitive binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeurotensin receptor type 1(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50130880(CHEMBL407196 | NT(1-13) | neurotensin | pGlu-Leu-T...)
Affinity DataKi:  1.20nMAssay Description:Binding affinity to human neurotensin receptor 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeurotensin receptor type 1(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50130880(CHEMBL407196 | NT(1-13) | neurotensin | pGlu-Leu-T...)
Affinity DataKi:  1.64nMAssay Description:Displacement of [125I]I-Tyr(3)NT from human NTR1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeurotensin receptor type 1(Rattus norvegicus)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50130880(CHEMBL407196 | NT(1-13) | neurotensin | pGlu-Leu-T...)
Affinity DataKi:  1.70nMAssay Description:Displacement of [125L]NT from rat neurotensin receptor type 1 expressed in CHOK1 cells by radioligand binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeurotensin receptor type 1(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50130880(CHEMBL407196 | NT(1-13) | neurotensin | pGlu-Leu-T...)
Affinity DataKi:  2.10nMAssay Description:Displacement of [3H]NT(8-13) from wild type human NTR1 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeurotensin(GUINEA PIG)
Hospital Saint-Antoine

Curated by PDSP Ki Database
LigandPNGBDBM50130880(CHEMBL407196 | NT(1-13) | neurotensin | pGlu-Leu-T...)
Affinity DataKi:  2.80nMMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetNeurotensin receptor type 1(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50130880(CHEMBL407196 | NT(1-13) | neurotensin | pGlu-Leu-T...)
Affinity DataKi:  3.30nMAssay Description:Displacement of [125I]Tyr3-neurotensin from human recombinant NTS1 stably expressed in CHO-K1 cell membranes incubated for 60 mins by gamma counter a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeurotensin receptor type 2(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50130880(CHEMBL407196 | NT(1-13) | neurotensin | pGlu-Leu-T...)
Affinity DataKi:  4.10nMAssay Description:Displacement of [125I]Tyr3-neurotensin from human recombinant NTS2 stably expressed in human 1321N1 cell membranes incubated for 60 mins by gamma cou...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeurotensin receptor type 2(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50130880(CHEMBL407196 | NT(1-13) | neurotensin | pGlu-Leu-T...)
Affinity DataKi:  4.90nMAssay Description:Displacement of [3H]NT from human NTS2 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeurotensin receptor type 2(Rattus norvegicus)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50130880(CHEMBL407196 | NT(1-13) | neurotensin | pGlu-Leu-T...)
Affinity DataKi:  19nMAssay Description:Displacement of [125I]NT at rat NTS2 overexpressed in CHOK1 cells after 30 mins by gamma countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeurotensin receptor type 2(Rattus norvegicus)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50130880(CHEMBL407196 | NT(1-13) | neurotensin | pGlu-Leu-T...)
Affinity DataKi:  21nMAssay Description:Displacement of [125L]NT from rat neurotensin receptor type 2 expressed in CHOK1 cells by radioligand binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeurotensin receptor type 2(Rattus norvegicus)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50130880(CHEMBL407196 | NT(1-13) | neurotensin | pGlu-Leu-T...)
Affinity DataKi:  28nMAssay Description:Displacement of [125I]neurotensin from rat NTS2 receptor expressed in CHO-K1 cells by competitive binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeurotensin(GUINEA PIG)
Hospital Saint-Antoine

Curated by PDSP Ki Database
LigandPNGBDBM50130880(CHEMBL407196 | NT(1-13) | neurotensin | pGlu-Leu-T...)
Affinity DataKi:  51nMMore data for this Ligand-Target Pair
In DepthDetails PubMed