BindingDB BDBM50274638 CHEMBL4126156::US10858355, Example 4

BDBM50274638 CHEMBL4126156::US10858355, Example 4

SMILES C[C@@H](C1CC1)N1Cc2cc(cc(c2C1=O)S(C)(=O)=O)-c1sc(NC(C)=O)nc1C

InChI Key InChIKey=PAQUFWFUOVDUIO-NSHDSACASA-N

Data 1 KI 18 IC50

Found 1 hit for monomerid = 50274638

P2Y purinoceptor 1(Homo sapiens (Human))
Pharmaron-Beijing

Curated by ChEMBL

BDBM50274638(CHEMBL4126156 | US10858355, Example 4)

Ki: <1.00E+3nMAssay Description:Binding affinity to human P2Y1 receptorMore data for this Ligand-Target Pair

Targets 13▿
- Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform 5
- Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform 3
- Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit delta isoform 1
- Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform 1
- Phosphatidylinositol 3-kinase catalytic subunit type 3 1
- Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit beta isoform 1
- P2Y purinoceptor 1 1
- Phosphatidylinositol 3-kinase C2 domain-containing subunit gamma 1
- Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform 1
- Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta 1
- Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha 1
- Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform 1
- Potassium voltage-gated channel subfamily H member 2 1
Publications 3▿
- J Med Chem 61: 5435-5441 (2018) 13
- J Med Chem 64: 8053-8075 (2021) 4
- US Patent US10858355 (2020) 2
Institutions 2▿
- Pharmaron-Beijing 13
- Astrazeneca 6
Affinity: 0.63 to 3.2E+4 nM▿
- Ki 1
- IC50 18
- Affinity ≤ nM
Xtal structures: 0
Docked structures: 0
Catalog Cmpds: 1