BDBM704252 4)::US12139488, Example 512

SMILES O=S(=O)(Nc1ccc(F)c(Nc2ncnc3ccc(-n4cnc5c(N6CC[C@@H](O)C6)nccc54)nc23)c1F)c1cccc(Cl)c1Cl

InChI Key InChIKey=QYQYFOCSAWUDSX-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 704252   

TargetSerine/threonine-protein kinase B-raf(Human)
Université

US Patent
LigandPNGBDBM704252(4) | US12139488, Example 512)
Affinity DataIC50: 5.5nMAssay Description:In vitro enzymatic reactions were used for evaluating compounds intrinsic activity against BRAF, CRAF and ARAF. For BRAF and CRAF, 0.375 nM of purifi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/18/2025
Entry Details
US Patent

TargetRAF proto-oncogene serine/threonine-protein kinase(Human)
Université

US Patent
LigandPNGBDBM704252(4) | US12139488, Example 512)
Affinity DataIC50: 10nMAssay Description:In vitro enzymatic reactions were used for evaluating compounds intrinsic activity against BRAF, CRAF and ARAF. For BRAF and CRAF, 0.375 nM of purifi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/18/2025
Entry Details
US Patent