BDBM50293576 4-(4-phenylthiazol-2-ylamino)phenol::4131JH0380::CHEMBL562493

SMILES Oc1ccc(Nc2nc(cs2)-c2ccccc2)cc1

InChI Key InChIKey=DERMXGZWGLKTNH-UHFFFAOYSA-N

Data  6 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50293576   

TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
Korea Research Institute of Chemical Technology

LigandPNGBDBM50293576(4-(4-phenylthiazol-2-ylamino)phenol | 4131JH0380 |...)
Affinity DataIC50:  110nMpH: 7.4 T: 25°CAssay Description:5-LOX enzyme assay was carried out with some modifications of ferric oxidation of xylenol orange (FOX) assay, which is based on the complex formation...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
Korea Research Institute of Chemical Technology

LigandPNGBDBM50293576(4-(4-phenylthiazol-2-ylamino)phenol | 4131JH0380 |...)
Affinity DataIC50:  100nMAssay Description:Inhibition of partially purified recombinant 5-lipoxygenase (unknown origin) using arachidonic acid as substrate preincubated for 15 mins before subs...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
Korea Research Institute of Chemical Technology

LigandPNGBDBM50293576(4-(4-phenylthiazol-2-ylamino)phenol | 4131JH0380 |...)
Affinity DataIC50:  300nMAssay Description:Inhibition of 5-lipoxygenase in human PMNL using arachidonic acid as substrate preincubated for 15 mins before substrate addition measured after 10 m...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetTransitional endoplasmic reticulum ATPase(Human)
Kyowa Hakko Kogyo

Curated by ChEMBL
LigandPNGBDBM50293576(4-(4-phenylthiazol-2-ylamino)phenol | 4131JH0380 |...)
Affinity DataIC50:  190nMAssay Description:Inhibition of VCP assessed as conversion of ATP to ADP by enzyme coupled glucokinase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetFructose-1,6-bisphosphatase 1(Pig)
Boston College

Curated by ChEMBL
LigandPNGBDBM50293576(4-(4-phenylthiazol-2-ylamino)phenol | 4131JH0380 |...)
Affinity DataIC50:  1.24E+5nMAssay Description:Inhibition of pig FBPase expressed in Escherichia coli EK1601 by spectrophotometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetTransitional endoplasmic reticulum ATPase(Human)
Kyowa Hakko Kogyo

Curated by ChEMBL
LigandPNGBDBM50293576(4-(4-phenylthiazol-2-ylamino)phenol | 4131JH0380 |...)
Affinity DataEC50:  520nMAssay Description:Inhibition of VCP in human HeLa cells assessed as stabilization of ubiquitin-tagged luciferase after 24 hrs by reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetAlpha-amylase 1A(Human)
Freie Universit£T Berlin

Curated by ChEMBL
LigandPNGBDBM50293576(4-(4-phenylthiazol-2-ylamino)phenol | 4131JH0380 |...)
Affinity DataIC50:  1.27E+6nMAssay Description:Inhibition of human salivary alpha-amylase using GalG2CNP as substrate by UV-Vis spectrophotometric analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed